文档介绍：Neuronal Electric Activities
神经元的电活动
主讲教师刘风雨万有

神经科学研究所、神经生物学系
Neuronal Electric Activities Include:
• Rest Potential (Chapter 3)
• Action Potential (Chapter 4)
• Local Potentials
– Post-Synaptic Potential
• Excitatory Post-Synaptic Potential
• Inhibitory Post-Synaptic Potential
– End-plate Potential
– Receptor Potential
Chapter 3
The Neuronal Membrane at Rest
• The CAST OF CHEMICALS
– Cytosol and Extracellular Fluid
– The Phospholipid Membrane
– Protein
• The MOVEMENT OF IONS
– Diffusion
– Electricity
• The IONIC BASIS OF RESTING MEMBRANE
POTENTIAL
– Equilibrium Potential
– The Distribution of Ions Across the Membrane
– Relative Ion Permeabilities of Membrane at Rest
– The Importance of Regulating the External Potassium
Concentration
• CONCLUDING REMARKS
Cytosol and Extracellular Fluid
• Water:
– Its uneven distribution
of electrical charge, so
H2O is a polar molecule
• Ions:
– Salt dissolves readily in
water because the
charged portions of the
water molecule have a
stronger attraction for
the ions than they have
for each other
The Phospholipid Membrane (磷脂膜)
The lipids of the neuronal
membrane forming:
z a barrier to water-soluble ions
z a barrier to water
头端-极性磷酸盐-亲水
尾端-非极性碳氢化合物
-疏水
5
Protein
• These proteins provide
routes for ions to cross
the neuronal membrane.
•The resting and action
potentials depend on
special proteins that
span the phospholipid
bilayer.
Protein – Amino Acids
The Peptide Bond (肽键) and
a Polypeptide (多肽)
Figure Protein Structure
The tertiary structure
The primary structure
The secondary structure
The quaternary structure
Each of the different polypeptides contributing to a protein with
quaternary structure is called a subunit (亚基).
Channel Proteins
• Channel protein is Figure A Membrane
suspended in a Ion Channel
phospholipid bilayer,
with its
– hydrophobic (疏水的)
portion i