文档介绍：Neurodegenerative
Diseases
崔德华(DH Chui, MD, PhD,)
博士生导师
Neuroscience, Research Institute and Dep. Of Neurobiology
Peking University , China
E-mail: ******@bjmu.
What Is Neurodegenerative
diseases
Hereditary and sporadic conditions which are
characterized by progressive nervous system
dysfunction.
These disorders are often associated with
atrophy (Apoptosis) of the affected central or
peripheral nervous system structures.
崔德华 DH Chui
Neurodegenerative Diseases
Alzheimer‘s Disease (AD) APP (chr 21) PS1 (chr 14 )PS2 (chr 1 )ApoE (chr 19)
Parkinson's Disease (PD) parkin gene alph-synuclein (autosoma)
Huntington's Disease(HD) CAG repead (chr 4)
Amyotrophic Lateral Sclerosis, ALS
Creutzfeldt-Jakob Disease(CJD)
Corticobasal degeneration (CBD)
Multi-infarct Dementia (MID)
Lewy Body Diseases (LBD)
Multiple system atrophy (MSA)
Progressive supranuclear palsy (PSP)
Pick's Disease
Heredodegenerative Disorders,
Paraneoplastic Syndromes,
Olivopontocerebellar Atrophies
Postpoliomyelitis Syndrome
崔德华 DH Chui
Neurodegenerative Diseases
Classification
1. 大脑皮层变性:包括Alzheimer病、Pick病、Creutzfeldt−Jakob病(海绵状变性)等。
2. 锥体外系统变性:包括Huntington病、Hallervorden−Spatz病、Wilson病(肝豆状核变
性)、Seitelberger病(神经轴索型营养不良)、进行性肌阵挛型癫痫。病损在中脑与纹状
体者有Parkinson(帕金森)病、纹状体黑质变性、进行性核上型麻痹(PSP)等。
3. 脑干小脑变性:包括各种小脑型共济失调、脊髓小脑变性、橄榄−桥脑−小脑变性
(OPCA)、Machado−Joseph病等。
4. 脊髓变性:包括进行性痉挛性截瘫、进行性后索变性、后侧索联合变性、Friedreich共
济失调等。
5. 运动系统变性:包括各型运动神经元病,如肌萎缩侧索硬化(ALS)、进行性脊髓性肌萎
缩(SMA)、进行性球麻痹等。
6. 自主神经系统变性:包括Riley−Day症候群(全自主神经功能不全)、Shy−Drager症候群
等。
7. 多系统变性(MSA):包括上述1、2、3、6等的混合类型。崔德华 DH Chui
Parkinson disease
崔德华 DH Chui
崔德华 Chui DH
What Is Alzheimer Disease ?

The Molecular Mechanisms of
Alzheimer Disease
Therapeutic Approach for
Alzheimer Disease
崔德华 DH Chui
Alzheimer Disease
奥古斯特(51)
"The first noticeable symptoms of the illness of this 51-year old woman
was suspiciousness of her husband. Soon, a rapidly increasing memory
impairment became e