文档介绍：降血压药物——昆布氨酸合成方法的研究
降血压药物一昆布氨酸合成方法的研究
学位论文完成日期：2Q!三：垒：!Q
辩论委员会成员签字：二§—灶指导教师签字：High blood
pressure seriOUS damage the human’S health．Laminine iS a basic amino acid that Was
discovered from kelp，which has pharmaceutical function of lowering blood pressure and blood lipid，and which Can prevent hypertension and cerebral hemorrhage． Laminine，which has not been listed at home and abroad at present，iS a new category drug of China．Laminine is rarely contented in the kelp．If Laminine is extracted from kelp，it will cause a lot of pollution．The cost of this method is too high SO it has no industrial production value．The chemical synthesis method was used to prepare an
antihypertensive drug-laminine．Aiming to achieve the clean production，a safe and low toxic green chemistry—DMC Was used as raw material，and the response surface methodology Was used to analyzed various factors influencing the reaction to optimize
the preparation technology．
The method of metal chelate was adopted to protect a-amino of lysine selectively． Lysine metal chelate was synthesized respectively by five kinds of metal ion-calcium， magnesium，copper,zinc and nickel and lysine as raw materials．By studying these
reactions copper ions was used as a-amino protective agen．Through the single factor
experiment，the best three factors which Can effect the reaction on yields are found to be the reaction temperature，time and pH of system，and the process Was optimized by response surface methodology．The best condition of preparation process is：the reaction temperature of 66℃，time of 2 hours，pH=7．5．Lysine copper Can be separated
and purified by 80％ethanol aqueous solution．The maximum yield is 93．1 5％．
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万方数据
Secondly,In the preparation experiments of s-N trimethyl lysine the DMC was used as methylating reagent．This p