文档介绍：雷公藤多苷片联合甲氨蝶呤治疗类风湿性关节炎的效果
[摘要] 目的探讨雷公藤多苷片联合甲氨蝶呤治疗类风湿性关节炎(RA)的效果。方法选取于2013年2月~2017年9月在成都军区总医院就诊的RA患者48例,按照随机数字表法将ody, AKA positive change of patients were compared between two groups, adverse reactions occurred in both groups were recorded. Results After treatment, the total efficiency of clinical efficacy evaluation in the observation group was better than that in the control group, and the difference was statistically significant (P < ). Before treatment, there were no significant difference in VAS score, number of tender joints, number of swollen joints, and time of morning stiffness between the two groups (P > ). After treatment, VAS score, number of tender joints, number of swollen joints, and time of morning stiffness in both groups were significantly reduced compared with those before treatment, and the observation group was significantly better than the control group, with statistically significant differences (P < ). After treatment, the above indicators of joint inflammation and biochemical correlation were lower in both groups than before treatment, and the observation group was significantly lower than the control group, with statistically significant differences (P < ). After treatment, the positive rates of anti-CCP antibodies and AKA antibodies in the two groups were lower than those before treatment, and the positive rates of anti- CCP antibodies and AKA antibodies in the observation group were significantly lower than those in the control group, with statistically significant differences (P < ). The adverse reactions in both groups were mild and controllable, and most of them could be alleviated by symptomatic drug therapy. Conclusion Tripterygium Polyglycoside Tablets combined with Methotrexate has a good clinical effect in the treatment of RA. It can effectively inhibit the expression of RF and the levels of IL-6, IL-1, TNF-α in peripheral blood serum, reduce the inflammatory reaction, effectively alleviate and improve t