文档介绍：Preparation, Characterization, Cytotoxicity, and Genotoxicity Evaluations of Thiolated- and S‑Nitrosated SuperparamagnetPreparation, Characterization, Cytotoxicity, and Genotoxicity Evaluations of Thiolated- and S‑Nitrosated Superparamagnetic Iron Oxide Nanoparticles: Implications for Cancer Treatment
Amedea B. Seabra,*,†Tatiane Pasquoto,‡Ana Carolina F. Ferrarini,†Marconi da Cruz Santos,†Paula S. Haddad,†and Renata de Lima
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Introduction
Result and discusion
Characterization of Thiolated Fe3O4 Nanoparticles.
The results revealed that thiolated nanoparticles
have low toxicity, whereas S-nitroso nanoparticles were observed to cause cytotoxic and genotoxic effects in different cell lines. Furthermore, the magnetic property of the S-nitrosated nanoparticles was used as a tool to generate a local cytotoxic effect directly at the target site of application. S-Nitrosated nanoparticles appear to constitute a potentially promising agent for the treatment of cancer and prevention of the metastatic cascade; therefore, further studies are required to clearly understand the complex and wide-ranging roles of NO to facilitate its therapeutic usage.
Conclusion