文档介绍：吲哚美辛缓释片的制备本科生毕业论文(设计) 吲哚美辛缓释片的处方研究与制备姓名: 巴晓静指导教师: 柯仲成院系: 化学化工学院专业: 制药工程提交日期: 2012 年3月 29日黄山学院本科毕业论文目录中文摘要??????????????????????????????2 外文摘要????????????????????????????3 引言????????????????????????????????4 1 实验部分?????????????????????????????6 仪器与试剂??????????????????????????6 标准曲线的建立????????????????????????7 缓释片的制备???????????????????????7 溶液的配制????????????????????????7 最大吸收波长的选择??? ?????????????????7 标准曲线的绘制??????????????????????7 溶液稳定性实验??????????????????????8 精密度实验????????????????????????9 回收率实验????????????????????????9 吲哚美辛缓释片的处方拟定与制备???????????????10 实验处方设计????????????????? ??????10 体外释放度考察??????????????????????10 2 实验结果分析与小结???????????????????????11 释放过程考察????????????????????????11 实验数据分析???????????????????????12 实验小结?????????????????????????13 3总结??????????????????????????????13 参考文献?????????????????????????????15 致谢???????????????????????????????16 -1- 黄山学院本科毕业论文吲哚美辛缓释片的处方研究与制备巴晓静指导老师:柯仲成(黄山学院化学化工学院,黄山,安徽 245041 ) 摘要:本文主要目的是为了改善吲哚美辛普通口服制剂的释药过程, 减少毒副作用, 提高患者顺应性, 将制成吲哚美辛缓释片。以亲水性羟丙甲基纤维素作为骨架材料, 采用湿法制粒压片制得, 然后通过紫外分光光度计在 320nm 波长下考察其体外释放度, 进行释药机制的研究。最后通过平行试验测定各处方在 2h、 6h、 12h 的累积释药量以及对其释药曲线的考察, 经过处方筛选, 最终优选得到最佳处方。结果表明采用处方 5所制备的缓释片具有良好的缓释效果,而且制备过程操作简单。关键词:吲哚美辛;缓释骨架片;释放度;处方筛选-2- 黄山学院本科毕业论文 Preparation and invitro Release of Indomethacin Sustained Release Tablets Ba Xiaojing Director : Ke Zhongcheng ( College of Chemistry and Chemical Engineering, Huangshan University, Huangshan, Anhui, 245041 ) Abstract : The main purpose of this paper is to improve oral mon preparation process of drug release, reduce toxicity, the patients pliance, and will be made into Indomethacin Sustained-release tables. The wather-soluble hydrophilic matrix HPMC(K4) was used to prepare sustaind-release tablets by the wet pression technique. The content of the major drug was determined by UV spectrophotometry at 320nm, the release mechanic was studied by determining the dissolution. Finally through the parallel tests d