文档介绍：1 孕中期妇女血清标志物测定筛查唐氏综合征【摘要】目的探讨孕中期妇女( 14~ 20w ) 外周血中甲胎蛋白( AFP ) 和游离绒毛膜促性腺激素( F-β hCG ) 在胎儿唐氏综合征产前筛查中的作用。方法采用酶联免疫吸附法检测孕妇血清 AFP 与 F-β hCG 浓度, 结合孕妇年龄、孕周, 利用配套软件计算胎儿患唐氏综合征的风险。结果筛查 789 例孕妇,筛出唐氏综合征高危孕妇 26 例,阳性率 %, 筛出神经管缺损高危 5 例。结论孕妇血清标记物筛查检测能显著降低需要进行创伤性产前诊断的孕妇比例, 降低唐氏儿出生几率。论文联盟。【关键词】产前筛查; 游离绒毛膜促性腺激素; 甲胎蛋白;唐氏综合征 Prenatal screening for Down syndrome by using of maternal serum markers 2 【 Abstract 】 Objective To investigate the effect of screening for Down syndrome by detecting serum AFP and F-β hCG in pregnant women(14 ~ 20 weeks).Methods Used a method based on dectecting maternal serum AFP and F-β hCG concentrations in pregnant women (14-20 weeks), bination with maternal age and gestational woman at risk for fetal DS were identified by analyses of puter Among 789 pregnant woman 29 case () were at high risk for DS .9 case were found with fetuses at high risk of neural tube Prenatal screening can reduce the need for invasive prenatal diagnosis,decreasing the birth rate of DS. 【 Key words 】 prenatal screening ; F-β hCG;AFP;Down syndrome 唐氏综合征( DS )又称 21- 三体综合征或先天愚型,为人类最先确认, 也是最为常见的一种染色体病。其发病率约为1: 600 ~1: 800 。主要特征是严重的先天智力障碍, 特殊 3 面容,并常伴有各种先天畸形。以往都是以孕妇年龄( ≥35 岁)作为唐氏综合征高风险的筛选指标,其检出率约 20% , 检出率偏低。近年来, 人们发现孕妇血清 AFP 和 F-β hCG 与唐氏综合征密切相关, 并将其用于产前筛查, 据报道可检出 93% 左右的唐氏综合征患儿[ 1] 。本文对 789 例孕妇唐氏综合征血清标志物进作筛查分析。现将结果报告如下。 1 对象与方法对象采用知情选择的原则,自 20