文档介绍:树枝状大分子
MARKETING
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. Caminade. Laboratoire de Chimie de Coordination du CNRS 205, route de Narbonne, 31077 Tou 17400
A unimolecular reverse micelle that efficiently catalyzes the elimination of tertiary halides. The nonpolar corona (yellow) shields the polar interior (blue) of hydroxyl functionalities, which are able to stabilize the carbocation intermediate.
. Piotti, F. Rivera, R. Bond, . Hawker, J. M. J. Frechet. J. . Soc. 1999, 121, 9471
催化剂方面的应用
Table 1. Effect of Changing the Dendrimer Structure and Concentration on the Yield and Turnover Number for the E1 Elimination Reaction (Reaction performed for 43 h at 70 oC
a The molar ratio.
Competitive Hydrogenations of 3-Cyclohexene-1-methanol and CyclohexeneUsing Various Pd Catalysts .Reaction conditions: 3-cyclohexene-1-methano l mmol, cyclohexene mmol, catalyst μmol of Pd, toluene mL, H2 1 atm, 30 oC.
树状大分子封装金属粒子
(1)小于4 nm纳米粒子,比表面积大、催化效率高
(2)表面基团控制——溶解性
(3)能很好的稳定纳米粒子,并创造纳米微环境
(4)能再生使用
M. Ooe, M. Murata, , K. Ebitani, K. Kaneda. Nano Lett. 2002, 2, 999
催化剂方面的应用
生物医学的应用
approaches for design of drug delivery systems.
药物载体
内部空腔和结合点可以携带药物。
高密度表面基团经过修饰,改变水溶性和靶向作用。
毒性较低,通过扩散和生物降解实现药物释放。
分子设计实现生物相溶性和降解性。
R. Duncan, L. Izzo. Advanced Drug Delivery Reviews. 2005, 57, 2215
外层用聚乙二醇修饰的聚芳醚类树形单分子胶束,疏水内层和亲水外层,在水溶液中有很强的增溶能力,每个胶束能包容9-10个疏水性消炎痛药物分子,具有明显的缓释作用。
Fig. 9. Structure of the G–2 dendritic unimolecular micelle.
药物载体
M. Liu, K. Kono , . Frechet. Journal of Controlled Release. 2000, 65, 121
Fig. 8. In vitro release profile of indomethacin from the G–3 dendritic unimolecular micelle.
病毒:它的体积也小,转染效率就相对较低.
核酸:容易受到细胞***的损害。
质粒DNA :易受到血浆和血清蛋白的降解.
脂质体:它有细胞毒性反应。
基因载体
U. Boas, . Heegaard. Chem. Soc. Rew. 2004, 33, 43.
. Tomalia. Prog. Polym. Sci.. 2005, 30, 294
生物医学的应用
. Top row: Three dimensional depiction of conformational change of an amino-terminated PAMAM dendrimer at increasing pH . Middle row: