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论文的主要结构
+genomic
instability
fromHanahanandWeinberg2000
SignalTransductionandCancer
LectureI:GrowthFactorsandReceptors
Outline:
WhatisSignalTransduction?
WhatareGrowthFactors?
HowdotheycontributetonormalST?
HowisthisSTderegulatedinCancer?
LectureI:GrowthFactorsandReceptors
WhatisSignalTransduction?
SignalTransductionistheprocessbywhichacell
convertsanextracellularsignalintoaresponse.
Involvedin:
Cell-cellcommunication
Cell’sresponsetoenvironment
Intracellularhomeostatsis-internalcommunication
ComponentsofSignalling
WhatcanbetheSignal?
Externalmessagetothecell
Peptides/Proteins-GrowthFactors
Aminoacidderivatives-epinephrine,histamine
Othersmallbiomolecules-ATP
Steroids,prostaglandins
Gases-NitricOxide(NO)
Photons
DamagedDNA
Odorants,tastants
Signal=LIGAND
Ligand-Amoleculethatbindstoaspecificsiteon
anothermolecule,usuallyaprotein,iereceptor
ComponentsofSignalling
WhatareReceptors?
Sensors,whatthesignal/ligandbindstoinitiateST
Cellsurface
Intracellular
HydrophillicLigand
Cell-Surface
Receptor
Plasmamembrane
Hydrophobic
Ligand
CarrierProtein
Intracellular
Receptor
Nucleus
AdaptedfromMolecularBiologyoftheCell,(2002),4thedition,Albertsetal.
CellSurfaceReceptorTypes:
Ligand-gatedionchannel
CellSurfaceReceptorTypes:
3)Enzyme-linkedReceptor
egGrowthFactorReceptors