文档介绍：HPV疫苗研究进展
天津市静海县医院王彦徐雅会
摘要:宫颈癌致病因素是高危型人乳头瘤病毒(HPV)的持续感染。高危型HPV基因组编码三个蛋白,E5,E6和E7,E6和E7主要在高级别病变和宫颈癌中表达,并是宫颈癌恶性表型发生和形成的必要条件。疫苗的靶点是所有早期癌蛋白,因此癌蛋白E6、E7是HPV疫苗治疗的主要干预靶点。目前,国际上已有多种HPV相关疫苗进入动物和临床试验阶段,HPV疫苗将在预防HPV感染及治疗由HPV感染所引起的相关疾病方面发挥重要作用。关键词: 人乳头瘤病毒;疫苗;进展
Progress in research on human papillomavirus ine XU Ya-hui ,WANG Yan. Tianjin Jinghai Hospital , Tianjin 301600 ,China Abstract: The risk factors of cervical cancer is the persistent infection of high-risk human papilloma virus. High-risk HPV genome encode three proteins, E5, E6 and E7. E6 and E7 are mainly expressed in high level lesions and cervical are the necessary condition for the occurrence and formation of malignancy. The targets of ine are all early oncoproteins, thus oncoprotein E6 and E7 are the main intervention targets in HPV ine treatment. At present, there have been a variety of HPV ine into animal and clinical trials in the world. HPV ine will play an important role in prevention HPV infection and treatment the related diseases of HPV infection.
Key words: human papillomavirus;ine; development
宫颈癌发病率居妇科恶性肿瘤首位,但由于宫颈脱落细胞学检查的普及,宫颈癌前病变及宫颈癌得到及早发现与治疗,尤其是发达国家还开展了人乳头瘤病毒(human papillomavirus,HPV)疫苗的接种,使浸润癌发病率明显减少。子宫颈上皮内瘤变(cervical intraepithelial neoplasia,CIN)的诊断大大提高宫颈癌患者的生存率以及改善患者对治疗的反应[1]。持续的HPV感染增加癌细胞转化风险,持续高危型HPV感染可改变细胞周期,使细胞易出现基因不稳定和致癌基因突变。在大多数情况下,免疫细胞可以清除这些感染,然而,只有一小部分的HPV感染者会发展为宫颈癌。因此免疫缺失,突变或内在的基因组