文档介绍：Drug Evaluation Research 第 35 卷第 1 期 2012 年 2 月- 31 -
活体肿瘤成像技术的研究进展
邰文,袁永兵,郑礼胜,陈常青*
天津药物研究院,天津 300193
摘要:成像技术在肿瘤生物学研究和临床诊断治疗中是不可或缺的工具之一,活体动物成像实验平台的主要优点是无创伤、
低成本、实时检测,而分子探针与活体荧光成像技术相结合对肿瘤的早期诊断具有重要意义。肿瘤的近红外荧光(NIRF)
成像技术依赖于稳定、高特异性和敏感性的分子探针。综述活体肿瘤成像技术的研究进展以及该项技术与新的分子探针、显
像剂、报告分子的协同作用,为进一步应用于临床肿瘤诊断和治疗打下基础。
关键词:活体肿瘤成像;近红外荧光(NIRF);分子探针;肿瘤诊断;荧光成像
中图分类号: 文献标志码:A 文章编号:1674 - 6376 (2012) 01 - 0031 - 05
Advances in studies on in vivo imaging of cancer
TAI Wen, YUAN Yong-bing, ZHENG Li-sheng, CHEN Chang-qing
Tianjin Institute of Pharmaceutical Research, Tianjin 300193, China
Abstract: Imaging technology is one of the indispensable tools in oncobiological research and clinical diagnosis and therapy. The
imaging experimental platform of in vivo animals has several advantages such as non-invasion, low cost, and real-time detection, and
bination of molecular probe and in vivo fluorescence imaging technique plays an important role in the early diagnosis of tumor.
Near-infrared fluorescence (NIFR) imaging of tumor depends on the molecular probes with stability, high-specificity, and sensitivity.
In the present paper, the research advance of in vivo tumor imaging and its synergism with novel molecular probes, imaging reagents,
and reporters are summarized so as to lay a foundation on applicating it in clinical diagnosis and therapy of tumor.
Key words: in v