文档介绍：Heart Failure
Department of pathophysiology Xiangrong Sun
2017/11/20
Fundamental knowledge
Heart is one of the most ans in body. The main function of heart is to providing impetus for circulation of blood.
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volume:like left fist
weight:≤500g
Ejection of blood:
70ml/SV×70/min ×60min×24h
=7056 L/d
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Histology of myocardium
Intercalated disc
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SR
mitochondrion
Ca2+
[Ca2+ ]10-7mol/L
[Ca2+ ]10-5mol/L
Release of Ca2+
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tropomyosin
contraction
(粗)myosin
(细)actin
troponin
Interaction point
Ca2+
ATPase
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[Ca2+ ]10-5mol/L
SR
mitochondrion
Ca2+
[Ca2+ ]10-7mol/L
Reuptake of Ca2+
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relaxation
tropomyosin
(粗)myosin
(细)actin
troponin
Interaction point
Ca2+
ATPase
2017/11/20