文档介绍：大柴胡汤加味治疗高血压病合并焦虑的疗效观察
[摘要] ?楣鄄齑蟛窈?汤加味对高血压病合并焦虑的临床疗效,将符合纳入标准的126例高血压病合并焦虑患者随机分为治疗组64例和对照组62例。治疗组和对照组均给予苯磺酸氨***地平片治疗,治疗组在基础西药治疗的基础上加服中药大柴胡汤加味,每日1剂,分2次服,每次100 mL,对照组给予***哌噻吨美利曲辛片。疗程4周。观察治疗前后2组患者的血压、中医证候、血脂、C反应蛋白、汉密尔顿焦虑量表及不良反应。结果发现,在血压方面,与治疗前相比2组患者治疗后的血压均显著下降(P
[关键词] 大柴胡汤;中医药;高血压病;焦虑
[Abstract] To observe the clinical efficacy of modified Da Chaihu decoction in treating essential hypertension with anxiety,the randomized,controlled,clinical trial was performed in this study. One hundred and twenty-six hypertensive patients with anxiety meeting the inclusive criteria were randomized into the treatment group and the control group. All of the included patients in the above 2 groups were treated by amlodipine besylate tablets. Patients in the treatment group were given Chinese herbal medicine modified Da Chaihu decoction every day. And patients in the control group were given flupentixol and melitracen tablets. The treatment course was 4 weeks. Blood pressure
,the score of traditional Chinese medicine syndrome,blood lipids,C reactive protein,the Hamilton anxiety scale score and adverse effects were observed. It has been identified that,both systolic and diastolic blood pressure were significantly reduced (P [Key words] Da Chaihu decoction;traditional Chinese medicine;hypertension;anxiety
高血压病是心血管疾病的重要危险因素,可以导致严重的心、脑、肾及血管病变,已经成为全球重大公共卫生问题[1-2]。目前,。近年来,越来越多的证据表明,焦虑抑郁与高血压、冠状动脉粥样硬化性心脏病、糖尿病等急慢性疾病密切相关[3-4]。流行病学研究发现,%~%[5]。Ginty等[6]研究发现,焦虑使非高血压人群的高血压风险增加2倍,焦虑影响血压的作用机制可能与激活肾素血管紧张素系统(renin-angioten-sin system,RAS),抑制副交感神经,激活交感神经,引起下丘脑-垂体-肾上腺轴(hypothalamic-pituitary-adrenal axis,HPAA)功能紊乱,一氧化氮(NO)和内皮素-1(ET-1)系统失衡[7-8]。然而,高血压也会进一步加重焦虑状态,两者互相影响。其治疗包括心理干预、常规降压治疗、抗焦虑抑郁治疗等。有研究显示,积极的心理干预能够显著改善高血压患者的焦虑抑郁状态。近年来,中医药治疗高血压的优势逐渐受到关注
[9-11],且越来越多的临床试验证实了中药治疗高血压合并焦虑状态的有效性[12-15]。大柴胡汤出自《伤寒论》,可主治少阳阳明合病,现多将本方加减化裁用于高血压、高脂血症、心律失常、糖尿病等疾病的治疗[16-17],笔者临证时将本方广泛用于高血压病合并焦虑状态的治疗,取得显著疗效。本文旨在探讨大柴胡汤对高血压病合并焦虑患者的血压、中医证候、血脂、C反应蛋白及焦虑的影响,及其安全性。
1 资料与方法
一般资料
126例病例均为201