文档介绍： Introduction of Cytokines Classification of CKs Biological Activities of CKs Cytokine Receptor (CKR) Clinical Application of CKs
Cytokines
细胞因子
Chapter 5
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Ⅰ.Introduction of cytokine (CK)
properties
feature
of CK
mon properties of CKs
---由免疫细胞及非免疫细胞经刺激而合成、分泌的一类具有多种生物活性的小分子蛋白质
properties
Low molecular-weight protein or glycoprotein (MW 15 ~30KD)
Monomer, dimer or trimer
Rapid reactivity and high efficiency (CK binding to CKR)
Nonspecific and non-MHC restriction
feature
Transient and self-restraint
Autocrine and paracrine
Endocrine
(also called immunohormone)
C. works
Multicellular sources
• T→IL2-6,9,10,13
• T,Mo/M→IL-1,6,10,GM-CSF
• pleiotropy (多效性) IFN-• overlapping(重叠性) IL-2,4,7,9,12 • two-way effects (双向性) TNF
Complexity of biological effects
Synergy & antagonism
• synergy IL1 and IL-4
• antagonism IFN- and TGF-
重叠性
IL-2,4,7,9,12
↓
T细胞增殖
双向性
抗肿瘤
↑适量
TNF
↓过量
BSS
(细菌性脓毒
血症休克)
协同作用
IL-1 IL-4
↓↓
B 细胞增殖
拮抗作用
IFN-
↓+ LAK细胞增殖
↑ˉ
TGF-
多效性
IFN-
LAK
B
Th2
NK
增殖
分化
分泌活性
杀伤活性
(IL-1 + IL-4)
(IL)
-1 to IL-22
effects
activate immune cells
take part in immunoregulation,
hematopoiesis and inflammation
reaction
白细胞介素是一组由由淋巴细胞或其他单个核細胞产生的介导白细胞间相互作用的细胞因子,也参与其他细胞的相互作用
Ⅱ.Classification of CKs
(IFN)
A. IFN-/(typeⅠ)
and IFN-(typeⅡ)
effects
antivirus
anti-tumor
immunoregulation
具有干扰病毒复制能力的细胞因子,故称干扰素
3. Tumor necrosis factor (TNF)
Anti-tumor
Take part in inflammation and
endotoxic shock
Regulate IR
- and TNF-
B. Biologic effects
(双向效应)
(内分泌,恶液质素)
(lymphotoxin, LT)
(homological trimer)
一类能引起肿瘤组织出血坏死的细胞因子,故称为肿瘤坏死因子
(直接杀死肿瘤细胞)
4. Colony stimulating factor (CSF)
kinds :G-CSF,M-CSF,GM-CSF, multi- CSF (IL-3 ), SCF, EPO,TPO and so on.
----是一类可选择性刺激造血干细胞增殖
分化为某一谱系细胞集落的细胞因子
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