文档介绍：雾化吸入布地奈德对肺纤维化大鼠肺组织MMP2、TIMP2表达的影响论文
张小波,范贤明,王文军,湛晓琴,曾鸣,朱晨
【摘要】目的探讨布地奈德雾化吸入对博莱霉素(BLM)致肺纤维化大鼠肺组织基质金属蛋白酶2(MMP2)及金属蛋白酶抑制剂2(TIMP2)表达的影响。方法组)、生理盐水空白对照组(NS组)和布地奈德干预组(Bud组)各15只, Fibrosis
Zhang Xiaobo, Fan Xianming, ing, Zhu Chen, the Attached Hospital to Luzhou Medical College, Luzhou, Sichuan Province 646000
ABSTRACT Objective To investigate the effect of inhaled budesonide on the expression of matix metalloproteinases2(MMP2) and tissue inhibitors of metalloproteinases 2 (TIMP2) in lung tissues of rats ycin-induced pulmonary fibrosis. Methods 45 ) group, the budesonide (Bud) group and the normal solution (NS) group. Intratracheal perfusion of BLM ade to the Bud group and the BLM group to induce pulmonary fibrosis al solution to the NS group in the same condition. From 0 to 6 days after perfusion, aerosol inhalation of Bud al saline to other groups in the same condition. On the 7th, 14th, and 28th day,.freel each group each time, and the lung tissues ine the extent of alveolitis and pulmonary fibrosis, and then the expression levels of MMP2 and TIMP2 in lung tissues onary fibrosis of the Bud group uch higher than those of the NS group (P<) but much louch higher than those in the NS group (P<) uch loeliorate the extent of bleomycin-induced alveolitis and pulmonary fibrosis in lung tissues of the rats, the intervention mechanism