文档介绍：10/17/05
Genes & Genomes
(formerly Gene Prediction - 1)
1
D Dobbs ISU - BCB 444/544X: Genes & Genomes
Gene Prediction & Regulation
Gene structure & regulation
Eukaryotes vs prokaryotes
Methods for predicting genes
Predicting regulatory regions
Predicting miRNAs & targets
2
D Dobbs ISU - BCB 444/544X: Genes & Genomes
Reading Assignment (for Mon)
Mount Bioinformatics
Chp 9 Gene Prediction & Regulation
pp 361-385 Eukaryotic vs Prokaryotic Gene Structure
Ck Errata: p/
Brown Genomes 2 (NCBI textbooks online)
Sect 7 Understanding a Genome Sequence - Overview
.gov/books/?rid=
Sect Locating Genes in a Genome Sequence
.gov/books/?rid=
3
D Dobbs ISU - BCB 444/544X: Genes & Genomes
Reading Assignment (for Wed)
Mount Bioinformatics
Chp 9 Gene Prediction & Regulation
pp 361-385 Predicting Promoters
Ck Errata: p/
Brown Genomes 2 (NCBI textbooks online)
Sect 9 Overview: Assembly of Transcription plex
.gov/books/?rid=
Sect - DNA binding proteins, Transcription initiation
.gov/books/?rid=
4
D Dobbs ISU - BCB 444/544X: Genes & Genomes
Eukaryotes vs Prokaryotes
Eukaryotic cells are characterized by membrane-partments, which are absent in prokaryotes.
“Typical” human & bacterial cells drawn to scale.
BIOS Scientific Publishers Ltd, 1999
Brown Fig
5
D Dobbs ISU - BCB 444/544X: Genes & Genomes
Central Dogma - “old”
BIOS Scientific Publishers Ltd, 1999
Brown Fig
6
D Dobbs ISU - BCB 444/544X: Genes & Genomes
Central Dogma - “new”
BIOS Scientific Publishers Ltd, 1999
Brown Fig
7
D Dobbs ISU - BCB 444/544X: Genes & Genomes
Central Dogma - “new”
BIOS Scientific Publishers Ltd, 1999
Brown Fig
8
D Dobbs ISU - BCB 444/544X: Genes & Genomes
Central Dogma - “new”
BIOS Scientific Publishers Ltd, 1999
Brown Fig
9
D Dobbs ISU - BCB 444/544X: Genes & Genomes
A very simple eukaryotic g