文档介绍：2/27/2006 3:18 PM Page iii
Exploiting Chemical Diversity
for Drug Discovery
Edited by
Paul A. Bartlett
Department of Chemistry, University of California, Berkeley
Michael Entzeroth
S*Bio Pte Ltd, Singapore
2/27/2006 3:18 PM Page iv
ISBN-10: 0-85404-842-1
ISBN-13: 978-0-85404-842-7
A catalogue record for this book is available from the British Library
© The Royal Society of Chemistry 2006
All rights reserved
Apart from fair dealing for the purposes of research for mercial purposes or for pri-
vate study, criticism or review, as permitted under the Copyright, Designs and Patents Act
1988 and the Copyright and Related Rights Regulations 2003, this publication may not be
reproduced, stored or transmitted, in any form or by any means, without the prior permission
in writing of The Royal Society of Chemistry, or in the case of reproduction in accordance
with the terms of licences issued by the Copyright Licensing Agency in the UK, or in accor-
dance with the terms of the licences issued by the appropriate Reproduction Rights
Organization outside the UK. Enquiries concerning reproduction outside the terms stated
here should be sent to The Royal Society of Chemistry at the address printed on this page.
Published by The Royal Society of Chemistry,
Thomas Graham House, Science Park, Milton Road,
Cambridge CB4 0WF, UK
Registered Charity Number 207890
For further information see our web site at
Typeset by Macmillan India Ltd, Bangalore, India
Printed by Henry Ling Ltd, Dorchester, Dorset, UK
2/4/2006 1:09 PM Page v
Preface
The methods of drug discovery in the pharmaceutical industry have changed dra-
matically in the last two decades. By the late 1980s, a strong belief had emerged that
drug development is purely a numbers game, with anticipated drop-out rates at each
stage of the process such that only pound out of 10,000 synthesized would
sur