文档介绍：L
Advanced Drug Delivery Reviews 45 (2000) 89–121
ate/drugdeliv
Microemulsion-based media as novel drug delivery systems
M. Jayne Lawrencea,** , Gareth D. Rees b,
aDepartment of Pharmacy, King’s College London, Franklin Wilkins Building, 150 Stamford Street, London SE19NN, UK
bSmithKline Beecham R&D, St. e’s Avenue, Weybridge, Surrey KT13 0DE, UK
Abstract
Microemulsions are clear, stable, isotropic mixtures of oil, water and surfactant, frequently bination with a
cosurfactant. These systems are currently of interest to the pharmaceutical scientist because of their considerable potential to
act as drug delivery vehicles by incorporating a wide range of drug molecules. In order to appreciate the potential of
microemulsions as delivery vehicles, this review gives an overview of the formation and phase behaviour and
characterization of microemulsions. The use of microemulsions and closely related microemulsion-based systems as drug
delivery vehicles is reviewed, with particular emphasis being placed on recent developments and future directions.  2000
Elsevier Science . All rights reserved.
Contents
1. Introduction ............................................................................................................................................................................ 90
2. Overview of microemulsion formation and phase behaviour ....................................................................................................... 92
. Theories of microemulsion formation ................................................................................................................................ 92
. Phase behaviour............................................................................................................................................................... 93
. The role of surfactant ................................................................................................................