固体自乳化释药系统的研究进展.pdf

文档介绍：广东药学院学报
Journal of Guangdong Pharmaceutical College Feb. 2011,271
固体自乳化释药系统的研究进展
叶珍珍,张建,廖华卫,崔升淼
,
广东药学院中药学院广东广州 510006
摘要固体自乳化释药系统可以提高难溶性药物的溶出度和生物利用度,具有巨大的发展潜力及应用前
景。本文综述固体自乳化释药系统的特点、辅料、制备方法及在新剂型中的应用。
关键词固体自乳化释药系统辅料制备应用
中图分类号 R944. 9 文献标识码 A doi 10. 3969 /j. issn. 1006-8783. 2011. 01. 027

文章编号 1006-8783 2011 01-0108-04
Development of solid self-emulsifying drug delivery systems
, , ,
YE Zhen-zhen ZHANG Jian LIAO Hua-wei CUI Sheng-miao
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Guangdong Pharmaceutical College Guangzhou Guangdong 510006 China
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Abstract The characterization excipients preparation techniques and application in new formulations of solid

self-emulsifying drug delivery systems S-SEDDS are expatiated according to the recent research of S-SEDDS.
The dissolution and the bioavailability of water - insoluble drugs can be improved by the utilization of S-
,
SEDDS therefore a promising application prospect of S-SEDDS can be expected in the field of medicine.

Key words solid self-emulsifying delivery systems excipients preparation application

自乳化释药系统 self-emulsifying drug delivery 物的通透性某些药用辅料可以抑制肠细胞色素 P450 对
, , ,
systems SEDDS 是由药物、油相、乳化剂和助乳化剂组成药物的催化以及 P-糖蛋白 P-gp 对药物的外排例如
[ ]
3 - 4
其基本特征是可在胃肠道内或轻微搅拌 37 ℃下自发形 Cremophor EL、Tween-80、PEG400 等该体系含有的脂
成水包油型乳剂粒径固体自乳化释药系统质成分可以促进药物的淋巴转运,避免首过效应及胃肠道
≤5 μm 。
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, 5
solid self-emulsifying d