文档介绍：吉西他滨联合顺铂治疗远处转移性鼻咽癌的效果观察
[摘要]目的观察吉西他滨+顺铂(GP方案)治疗转移性鼻咽癌的近期效果及不良反应。方法将2015年7月~2016年5月我院收治的46例远处转移性鼻咽癌患者随机分为观察组和对照组,各23例。其中观察组采用GP方案静脉点滴全身化疗,吉西他滨1000 mg/m2,d1、d8;顺铂25 mg/m2,d1~d3。对照组采用顺铂25 mg/m2,d1~d3;*** mg/m2,d1~d5。21 d为1个周期,全部完成4个周期化疗。比较两组治疗效果和毒副作用发生情况。结果观察组治疗客观有效率、疾病控制率均显著高于对照组(% vs %;% vs %)()。结论 GP方案对转移性鼻咽癌有较好近期疗效,且毒副作用较轻,可作为转移性鼻咽癌的一线化疗。
[关键词]吉西他滨;顺铂;鼻咽癌;化学治疗
[中图分类号] [文献标识码] A [文章编号] 1674-4721(2016)10(c)-0072-03
[Abstract]Objective To observe the short-term efficacy and adverse reaction of Gemcitabine plus Cisplatin(GP regimen) in the treatment of metastatic nasopharyngeal carcinoma (NPC).Methods 46 patients with metastatic NPC treated in our hospital from July 2015 to May 2016 were randomly divided in
to observation group and control group,23 cases in each the observation group,GP regimen was used for intravenous drip chemotherapy,with Gemcitabine 1000 mg/m2,d1,d8;Cisplatin 25 mg/m2,d1- in the control group were given Cisplatin 25 mg/m2,d1-d3;FU mg/m2, d1- days for a cycle,the whole chemotherapy contained 4 therapeutic effect and side effects of the patients were The objective effective rate and disease control rate in the observation group was significantly higher than that in the control group(% vs %;% vs %) ().Conclusion GP regimen has a good s