文档介绍：综述
快速老化动物模型SAMP8小鼠及其相关研究进展☆
苑振云1,3,顾平2,3,刘静3,王铭维2,3
Progress in accelerated senescence animal models of SAMP8 mice
Yuan Zhen-yun1,3, Gu Ping2,3, Liu Jing3, Wang Ming-wei2,3
1Department of Emergency, 2Department of Neurology, First Hospital of Hebei Medical University, Shijiazhuang 050031, Hebei Province, China; 3Brain Aging and Cognitive Neuroscience Laboratory of Hebei Province, Shijiazhuang 050031, Hebei Province, China
Yuan Zhen-yun☆, Studying for doctorate, Associate chief physician, Department of Emergency, First Hospital of Hebei Medical University, Shijiazhuang 050031, Hebei Province, China; Brain Aging and Cognitive Neuroscience Laboratory of Hebei Province, Shijiazhuang 050031, Hebei Province, China
Yuanzy2001@
Correspondence to: Wang Ming-wei, Professor, Chief physician, Doctoral supervisor, Department of Neurology, First Hospital of Hebei Medical University, Shijiazhuang 050031, Hebei Province, China; Brain Aging and Cognitive Neuroscience Laboratory of Hebei Province, Shijiazhuang 050031, Hebei Province, China
******@hebmu.
Received: 2008-05-09
Accepted: 2008-07-15
Abstract: SAMP8 mouse was established by Professor Takeda in Japan Kyoto University, which has the characteristics of age-related learning and memory impairment and pathological changes of cerebral cortex and hippocampus in central nerve system. SAMP8 is an ideal model for studying brain ageing a