文档介绍：《中国癌症杂志》2010年第20卷第4期
CHINA ONCOLOGY 2010 299
胫琢龉叵档难芯拷
江黎珠综述陈鸿雁审校
重庆医科大学附属第一医院耳鼻咽喉科,重庆 400016
[摘要] WIF-1是Wnt/β-catenin信号通路的重要拮抗物之一。WIF-1作为一种抑癌基因,被发现在大多
数肿瘤中表达降低,这与其启动子甲基化密切相关,而经去甲基化剂作用可恢复其表达。启动子甲基化导致的
WIF-1抑癌作用的丧失可能主要通过异常激活Wnt/β-catenin信号通路而促进了肿瘤的发生。在不同肿瘤中,
WIF-1表达降低与临床病理参数之间的关系有差异性。检测WIF-1表达及启动子甲基化水平可能为肿瘤早期诊
断、治疗及判断预后提供帮助。
[关键词] WIF-1; 抑癌基因; 甲基化; Wnt; 肿瘤
中图分类号: 文献标识码:A 文章编号:1007-3639(2010)04-0299-04
Research progresses on relationship between Wnt inhibitory factor-1 and tumor JIANG Li-zhu,
CHEN Hong-yan (Department of Otorhinolaryngology, the First Affiliated Hospital of
Chongqing Medical University , Chongqing 400016, China)
Correspondence to:CHEN Hong-yan E-hhyy787@
[Abstract] WIF-1 is an important antagonist in the Wnt/β-catenin pathway. As a tumor suppressor, WIF-1 is
down-regulated in majority cancers but when it is correlated with WIF-1 promoter hypermethylation and treated with
demethylation drug, its expression can be restored. Functional loss of WIF-1 due to promoter hypermethylation plays an
important role in a tumor’s pathogenesis, possibly mainly through aberrant canonical Wnt/β-catenin signal activation.
The correlation of the expression of WIF-1 with clinicopathological features in different cancers is not identical.
Detecting WIF-1 and promoter hypermethylation may offer help for early diagnosi