丹皮酚微乳的制备及经皮吸收研究.doc

文档介绍：丹皮酚微乳的制备及经皮吸收研究
韩盈,刘继勇,李凤前,彭程,孙华君,胡晋红作者简介:韩盈(1983-),女,汉族,硕士研究生。E-mail:beibei3690@。
通讯作者:Tel:[phone],Fax:[phone],E-mail: ******@smmu.。
(第二军医大学长海医院药学部,上海 200433)
摘要:选择适宜比例的油相、表面活性剂、助表面活性剂、水相制备丹皮酚微乳制剂以增加药物溶解度和经皮渗透量,优化处方,并对其理化性质进行研究。通过绘制伪三元相图研究形成O/W微乳的区域和能力;以单位面积累积渗透量为指标,优化处方;并考察了制剂的外观、形态、粒径分布等理化性质。处方选用肉豆蔻酸异丙酯(IPM)为油相,lecithin为表面活性剂,聚氧乙烯辛基苯基醚(OP)为助表面活性剂;微乳中Lecithin与OP比例为3∶7时,O/W微乳区最大,确定了5个处方。通过处方筛选确定了最佳处方,制备出澄清透明、平均粒径为(±)nm的丹皮酚微乳制剂。
关键词:丹皮酚;微乳;伪三元相图;经皮给药;体外评价
Preparation and in vitro transdermal permeation of paeonol microemulsion
Han-Ying,LIU Ji-Yong,Li Feng-Qian,Peng-Cheng,SUN Hua-jun,HU Jin-Hong*
(Department of Pharmacy,Changhai Hospital,Second Military Medical University,Shanghai 200433,China)
Abstract: To prepare the microemulsion of paeonol in order to increase solubility and its in vitro transdermal delivery by using appropriate proportion of oil,surfactant(S),cosurfactant(CoS) and formulation of proportion was physicochemical properties of the microemulsion was studied. Pseudo—tertiary phase diagrams were prepared to obtain the area and ability of O/W microemulsion formation. Using in vitro cumulative amount permeated as index, optimize the formulation of microemulsion. The physicochemical properties including appearance, particle size distribution and shape were examined. IPM was selected as oil, lecithin and OP were used as