文档介绍：伊班膦酸钠对钛颗粒诱导的骨溶解作用
【摘要】[目的]通过建立钛颗粒诱导的小鼠颅骨骨溶解动物模型,研究伊班膦酸钠对骨溶解的影响,并探讨其作用机制。[方法]24只昆明系小鼠随机分成4组,每组6只,建立钛颗粒诱导的小鼠颅骨骨溶解模型。空白对照组进行假手术;钛颗粒组在小鼠颅顶植入30 mg钛颗粒;1单位伊班膦酸钠组和10单位伊班膦酸钠组分别于植入钛颗粒第2 d腹腔注射伊班膦酸钠10 mg、100 mg。手术后第10 d,取出颅骨进行病理学分析。[结果]空白对照组骨溶解面积为(±)mm2,没有发生明显骨溶解。钛颗粒组骨溶解面积为(±)mm2,和空白对照组相比发生了更大面积的骨溶解(P&lt;)。1单位伊班膦酸钠组和10单位伊班膦酸钠组骨溶解面积分别为(±)mm2、(±)mm2,均小于钛颗粒组骨溶解面积(P&lt;)。而且10单位伊班膦酸钠组比1单位伊班膦酸钠组骨溶解面积更小(P&lt;)。骨溶解区域破骨细胞数量各组比较结果和骨溶解面积结果类似。[结论]伊班膦酸钠能够有效抑制钛颗粒诱导的小鼠颅骨骨溶解。
【关键词】人工关节; 无菌性松动; 骨溶解; 钛颗粒; 伊班膦酸钠
Abstract:[Objective]Titanium particle induced mouse calvarial osteolysis model was used to investigate the effects and mechanisms of sodium ibandronate on osteolysis.[Methods]Twentyfour Kunming species mice were randomly divided into 4 groups, 6 in each group. Control group received sham operation. Titanium particle group received 30 mg titanium particle implantation onto the calvariae. One unit sodium ibandronate group and 10 units sodium ibandronate group r
eceived 10 mg and 100mg sodium ibandronate ip injection separately on the next day of titanium particles days later,mice calvariae were harvested for pathology analysis.[Results]In control group osteolysis area was (±)mm2 and osteolysis was not apparent. In titanium particle group osteolysis area(±) mm2 was bigger than that of control group(P&lt;