文档介绍：E ,VA 对梭曼致大鼠过氧化损伤的保护作用
作者:赵燕,杨兴斌,海春旭,冯安吉,李晓晔
【关键词】自由基
关键词: 维生素E;维生素A;梭曼;自由基
摘要:目的研究梭曼(soman)对大鼠急性中毒的自由基损伤作用及V
E /VA 的抗氧化保护作用. 方法雄性大鼠40只,按体质量随机分为阴性组(正常对照组)、阳性组(损伤对照组),VE 组(加VE 保护组)和VA 组(加VA 保护组).观察每组大鼠血清、大脑、肝脏中VE 、总抗氧化力(T-AOC)和一氧化氮合成酶(NOS)的变化. 结果梭曼中毒后,T-AOC水平、VE 含量下降, 质量分数从(±)mg g-1 下降至(±)mg g-1 ;T-AOC从(±)mol s-1 kg-1 下降至(±)mol s-1 kg-1 ;NOS从(±)mol s-1 kg-1 上升至(±)mol s-1 kg-1 ,有显著差异(P<).而VE /VA 较有效地抑制其变化. 结论梭曼中毒有明显的过氧化损伤作用,VE /VA 对梭曼中毒有一定的抗氧化保护作用.
Keywords:vitamin E;vitamin A;soman;free radical
Abstract:AIM To study the effects of free radical injury in-duced by soman in rats and antioxidation of VE /VA .METHODS 40male rats were randomly divided into4groups according to weights,.,negative group,positive group,VE group and VA serum,cerebrums and liver VE,NOS and T-AOC(total antioxidative capacity)were The VE contents,T-AOC lev-el decreased and NOS activities increased after soman intoxi- liver,VE contents decreased from(±)mg g-1 to(±)mg g-1 and T-AOC level decreased from(±)mol s-1 kg-1 to(±)mol s-1 kg-1 (P<),and NOS activities increased from(±)mol s-1 kg-1 to(±)mol s-1 kg-1 (P<).And the VE /VA inhibited the change ┐SION There is mechanism of free radical injury by