文档介绍：浅议荭叶心通软胶囊成型工艺
【摘要】目的: 确定荭叶心通软胶囊的最佳成型工艺。方法: 采用单因素平行试验的方法,对辅料及其用量、囊材、制片温度等进行了成型工艺筛选。结果: 最佳工艺是以适量的大豆油作为混悬剂,并加入助悬剂蜂蜡(2%),先熔融在大豆油中,冷至室温后,加入挥发油混匀,再将干膏粉加入混合油充分研磨混匀(比例为1∶~1∶),采用明胶∶甘油∶水(质量比 1∶∶1 )为囊材,融胶温度在70~80 ℃、保温温度在 55~65 ℃时制成软胶囊。结论: 此成型工艺合理、稳定,操作简单,适用于大规模生产。
【关键词】红蓼; 软胶囊; 蜂蜡; 油类; 荭叶心通软胶囊
[Abstract] Objective: To optimize the shaping technology of Hongyexintong soft capsules. Methods: Single factor parallel experimental method was adopted to screen the shaping processes in terms of adjuvant category and amount, material of capsule, and processing temperatures. Results: The optimized shaping process was as follows: Sufficient amount of soybean oil was added with beeswax (2%), cooled to room temperature after the beeswax being melted by heating. The oil mixture was blended with naphtha and dried extracts in the ratio range of 1∶~1∶ and shaped. The materials and ratio that formed the capsule hull were glutin∶glycerol∶water=1∶∶1. The gel-thawing temperature was 70~80 ℃, and the shaping temperature 55~65
℃. Conclusion: The shaping process is reproducible and applicable to Hongyexintong soft capsules production in large scale.
[Key words] Polygonum orientale; soft capsules; ceraflava; oils; Hongyexintong Soft Capsules
荭叶心通软胶囊源于民间验方,由荭草等多味中药组成,通常以汤剂入药,用于治疗胸痛、胸闷、气短等冠心病心绞痛心血瘀阻证。由于汤剂存在携带、服用不便,质量不易控制等缺点,使临床推广应用受到限制。为制备质量稳定可控,临床使用安全、有效,贮藏、运输、携带、使用方便的剂型,根据本品含有挥发性成分