文档介绍：莪黄糖肾合剂对早期糖尿病肾病患者尿微量白蛋白排泄率及内皮素-1和一氧化氮的影响
作者:安向平檀金川戴剑华
【摘要】目的观察莪黄糖肾合剂对早期糖尿病肾病(DN)患者尿微量白蛋白排泄率(UAER)及血浆内皮素-1(ET-1)和血浆一氧化氮(NO)的影响。方法将98例早期DN患者随机分为2组,在继续降糖治疗基础上,治疗组49例给予莪黄糖肾合剂治疗,对照组49例予贝那普利片(洛汀新)治疗,观察UAER、ET-1及NO水平变化。结果 2组治疗后UAER、ET-1均明显下降(P<),2组间比较差异无统计学意义(P>);治疗组NO水平明显下降,与治疗前比较差异有统计学意义(P<);对照组治疗后NO水平虽有下降,但与治疗前比较差异无统计学意义(P>)。结论莪黄糖肾合剂可明显降低早期DN患者UAER、ET-1和NO水平,降低早期DN患者UAER的机制与其降低ET-1、NO水平有关。
【关键词】莪黄糖肾合剂早期糖尿病肾病尿微量白蛋白排泄率内皮素-1 一氧化氮
【Abstract】 Objective To observe the effect of position on urinary albumen excretion rate (UAER), ET-1 and NO in patients with early diabetic nephropathy. Methods 98 patients with early diabetic nephropathy were randomly divided into 2 groups, the treatment group and the control group. All the cases in the both groups received treatment of controlling blood glucose. The cases in treatment group (n=49) were treated with position and the cases in control group (n=49) were treated with Lotensin. The therapeutic course was three months in both groups. UAER, ET-1 and NO in patients were observed before and after the treatment. Results UAER and ET-1 in two groups significantly decreased after treatment parison with those before treatment (P&lt;). But there was no difference between two groups after treatment (P&gt;). The level of NO in treatment group obviously decreased after pared with that before treatment (P&lt;). There was no