文档介绍:结直肠癌中TXNIP基因与Kiss-1基因表达的关系及其临床意义林素勇陈绍勤戴起宝陈志华(福建医科大学附属第一医院胃肠外科福建福州350005)【摘要】冃的:探讨TXNIP基因与Kiss-1基因在结直肠癌屮表达的相关性以及TXNIP基因与结直肠癌临床病理特性的关系。方法:采用免疫组化方法检测71例结直肠癌组织中TXNIP基因与Kiss-1基因的蛋白表达水平,RT-PCR方法分析51例结直肠癌组织中TXNIP与KissJ基因基因的mRNA水平。结果:免疫组化和RT-PCR结果均表明在结直肠癌组织屮TXNIP基因与Kiss-1基因的表达呈明显正相关性(P<)o在结直肠癌组织屮,伴淋巴结转移组、、无远处转移组和DukesA、B期组(P<)。结论:TXNIP基因与Kiss-1基因在结直肠癌组织中的表达可能存在正相关,TXNIP基因可能与结直肠癌转移抑制基因Kiss-1具有相近的生物学功能,对结直肠癌的转移存在抑制作用。【关键词】TXNIP基因Kiss-1基因结直肠癌转移【屮图分类号】R73-3 【文献标识码】A 【文章编号】2095-1752(2014)15-0133-03TherelationshipbetweeenTXNIPgenewithKiss-1geneandtheclinicalsignificaneeincolotectalcarcinomaLinsuyong,ChenShaoqin,DaiQibao,ChenZhihua,Chenlihua・Departmentofgastrointestinalsurgery,ThefirstaffiliatedhospitalofFujianMedicalUniversity・FujianFuzhou350005,China[Abstract]ObjectiveToresearchtherelationshipbetweentheTXNIPgenewiththeKiss-1geneincolorectalcarcinoma,-1geneweredetectedbyIHCin71casesofcolorectalcarcinoma,andalsodetectedbyRT--1gene(P<).Inthecancertissue,thepositiveexpressionrateofTXNIPgeneoflymphnodemetastasis,distantmetastasisandtheDukesC、Dwerelowerthanthenegativelymphnodemetastasis,negativedistantmetastasisandDukesA、B(P<).Conc