文档介绍：Aging and cancer cell biology
《 Aging Cell》
diminished activity of the tumor-suppressor gene p16/
INK4a, while increasing the risk of cancer mortality,
can lead to improved function in several varieties of
age-sensitive stem cells.
Summary
the ability of Mdm2 mutations to
diminish risks of cancer in aging mice
Cancer is a major age-related disease and threat to the longevity anisms
with renewable tissues such as mammals. Although similar in its trajectory to the degenerative diseases of aging, cancer is not in essence a degenerative disease. Rather, malignant tumors arise from hyperproliferative cells – cells that develop derangements in the beneficial processes designed to promote tissue renewal and repair. Cancer is suppressed by the activities of tumor suppressor genes, some of which act to eliminate or permanently arrest the growth of potential cancer cells through the processes of apoptosis or cellular senescence, respectively.
Cancer
These reports suggested that activity of the p53 tumor suppressor protein might suppress cancer at the cost of accelerating aging.
a potential target for pharmacologically harnessing the tumor suppressor activity of p53 without proaging side-effects
By way of background, the findings that p53 can, under some
circumstances, cause phenotypes that resemble some aspects
of aging provided a platform from which molecular links
between aging and cancer could be studied. p53 is a critically
important tumor suppressor protein that acts in the nucleus and
mitochondria to orchestrate both the apoptotic and senescence
responses to potentially oncogenic insults.
Also in the last year,three articles described the role of the p16/INK4a tumor suppressor in regulating stem cell proliferation, and suggested that age- ependent engagement of the circuits that suppress cancer progression in young mice also contribute to age-related changes in immune system maintenance, olfactory neurogenesis, and pancreatic β-cell function.
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