文档介绍：生理学报 Acta Physiologica Sinica, June 25, 2012, 64(3): 341–345 341
综述
腺苷酸活化蛋白激酶:炎症调控新靶点
姚烽1,2,汲广岩1,张力2,*
重庆医科大学1临床学院;2病理生理学教研室,重庆 400016
摘要:腺苷酸活化蛋白激酶(AMP-activated protein kinase, AMPK)是参与调节糖、脂肪和蛋白质的代谢,维持细胞能量稳态
的关键丝氨酸/苏氨酸蛋白激酶。新近研究表明:AMPK可通过磷酸化SIRT1、PGC-lα、p53和FoxO3a等下调核因子-κB的活
性、抑制炎症相关基因的表达并减轻组织炎症损伤;此外,临床常用的降糖药二甲双胍也可通过激活AMPK而减轻炎症损
伤。因而,AMPK将成为极具前景的抗炎药物开发新靶点。本文就AMPK的炎症调控效应及其分子机制作一综述。
关键词:腺苷酸活化蛋白激酶;炎症;核因子-κB;二甲双胍
中图分类号:;Q55
AMPK: a novel target controlling inflammation
YAO Feng1,2, JI Guang-Yan1, ZHANG Li2,*
1College of Clinical Medicine; 2Department of Pathophysiology, Chongqing Medical University, Chongqing 400016, China
Abstract: The AMP-activated protein kinase (AMPK) is a pivotal serine/threonine kinase participating in the regulation of glucose,
lipid as well as protein metabolism and maintenance of energy homeostasis. Recent studies demonstrated that AMPK can also inhibit
nuclear factor-κB, suppress the expression of inflammatory genes and attenuate inflammatory injury through phosphorylating its
downstream targets including SIRT1, PGC-lα, p53 and FoxO3a. In addition, the widely used antidiabetic metformin also exerts its anti-
inflammatory effects through activating AMPK. Therefore, AMPK is emerging as a promising novel target for the development of
anti-inflammatory drugs. This review summarized the anti-inflammatory effects of AMPK and th