文档介绍：64层螺旋CT灌注成像在食管癌放疗中的应用
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【摘要】目的: 探讨64层螺旋CT灌注成像在食管癌放疗方面的价值。方法: 38例经病理学证实的食管癌患者在放疗前后分别行64层螺旋CT灌注扫描,将放疗前、后的灌注参数进行配对设计t检验。放疗后随访12~18个月,中位时间15个月,再以是否局部复发和(或)转移为标准进行分组,并对各组病例放疗前肿瘤灌注参数进行独立样本t检验。结果: 38例放疗前组织血流量、血容量、表面通透性、平均通过时间、强化峰值分别为(±) ml ·100 g-1·min-1, (±)ml·100 g-1,(±) ml·100 g-1·min-1,(±) s,(±) Hu,放疗灌注后参数分别为(±) ml·100 g-1·min-1,(±)ml·100 g-1, (±)ml·100 g-1·min-1, (±)s, (±)Hu。肿瘤表面通透性,强化峰值差异有统计学意义。其余各参数之间比较差异无统计学意义。复发/转移组与无复发/转移组灌注参数差异无统计学意义。结论: 灌注参数可以定量反映食管癌的微循环特征。放疗前和放疗后肿瘤表面通透性、强化峰值表现为明显减低。灌注参数难以预测肿瘤放疗后复发及转移。
【关键词】螺旋CT; 食管肿瘤; 灌注成像; 放射治疗
[Abstract] Objective: To assess the value of 64slice spiral CT in diagnosis of esophageal carcinoma and prediction. Methods: thirtyeight cases of esophageal carcinoma proved by nasopharyngoscopy biopsy underwent 64slice CT perfusion imaging before radiotherapy, paired samples ttest was used to analys the perfusion parameters of preradiation and postradiation, 38 cases were followed up for 12~18 months,with median of 15 months. The cases were divided into groups according to whether they had local recurrence or/and metastasis. The parameters of those groups before radiotherapy were assessed with independentsample ttest. Results: Before radiotherapy, the tissue blood flow(BF), blood volume(BV),surface permeability(PS)