文档介绍：88例重型颅脑损伤的临床治疗研究
(作者:___________单位: ___________邮编: ___________)
作者:刘晓祥杜忠胜明大庆宁新玲孙洪玉
【摘要】目的探讨常规治疗和应用神经节苷脂(GM1)治疗重型颅脑损伤的临床效果。方法 88例重型颅脑损伤病例随机分为GM1治疗组(n=46)和对照组(n=42),对照组进行常规治疗,GM1治疗组在常规治疗的基础上使用GM1,观察治疗时期两组病人的颅脑CT、生命体征的变化,并对两组患者进行GCS评分、NFD评分及2个月后GOS评分,以此评定两组患者的预后。结果 GM1治疗组病人呼吸异常(%)和心律异常(%)均较对照组显著减少(),重度脑水肿(%)的发生也较对照组明显减少();治疗10 d后治疗组GCS分值较对照组提高,神经功能缺失(NFD)评分较对照组降低,随访2个月GOS评分Ⅴ级者(%),较对照组(%)提高(P<005)。结论 GM1可减轻脑水肿,降低颅内压,改善脑供血,促进患者神经功能恢复,改善预后。
【关键词】神经节苷脂;颅脑损伤;治疗

【Abstract】 Objective To study the clinical effects of routine treatment and GM
1 for acute severe traumatic brain 88 patients with acute severe traumatic brain injury were randomly divided into GM1 treatment group (n=46) and control group (n=42). The two groups both received routine treatment, but the treatment group was also treated with GM1. The clinical data, including vital signs, cerebral edema, GCS score, NFD score and GOS score, were observed after treatment. Results The fluctuation of vital signs was smoother in GM1 treatment group than control group, including arrhythmia () and abnormal respiration (). CT scanning showed that the severity of brain edema was less remarkable (). More patients revived in GM1 treatment group than control group () in 10 days panied by higher recovery rate of neurologic impairment () and lower