AFU与AFP联合检测在诊断原发性肝癌中的应用.doc

文档介绍：AFU与AFP联合检测在诊断原发性肝癌中的应用
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【摘要】目的探讨血清α-L-岩藻糖苷酶(AFU)及甲胎蛋白(AFP)对原发性肝癌(PHC)的诊断价值。方法分别测定29例PHC患者、28例肝硬化患者、103例其他肝损伤疾病患者的AFU及AFP含量。结果 %%,在AFP阴性的PHC患者中,AFU的阳性率为84%,%。结论 AFU与AFP联合检测对提高PHC的诊断率有重要价值。
【关键词】原发性肝癌;α-L-岩藻糖苷酶;甲胎蛋白
【Abstract】 Objective To study the significance of serum α-L-fucosidase (AFU) and fetoprotein(AFP) in the diagnosis of primary hepatic carcinoma(PHC). Methods The activities of serum AFU and AFP were measured in 29 cases of PHC ,28 cases of liver cirrhosis ,103 cases of others liver damage. Results The activity in patients with PHC were significantly higher than any other groups. The diagnostic sensitivities of serm AFU and AFP in patients with PHC were % and % respectively. Get in the AFP negative gender inside,AFU is %,and bined diagnostic sensitivity of AFU and AFP reached the level of %. Conclusion The serum AFU and AFP were a useful marker for the diagnosis of
PHC.
【Key words】α-L-fucosidase;alpha fetoprotein;primary hepatic carcinoma
AFP是诊断原发性肝癌(PHC)最特异的肿瘤标志物,但并非所有肝癌患者都能分泌大量AFP,根据报道早期PHC的40%及晚期15%~20%患者血清AFP水平是正常的[1]。AFU是存在于多种组织中的一种溶酶体酶,近年来AFU在PHC患者血清中高水平检出而受到广泛关注[2,3],现就血清AFU与AFP对PHC诊断意义进行探讨。
1 资料与方法
研究对象 PHC 29例,肝硬化28例,以上患者均为本院住院病人,其诊断经病理及影像学证实,肝损伤(非PHC、肝硬化)患者103例。
方法与试剂病人清晨空腹抽取静脉血3ml分离血清,在-20℃保存待测。血清AFU单位以u/ml表示,以AFU10作为判定PHC的临界标准