文档介绍：CYP1A1基因多态性与女性子宫内膜癌易感性关系的Meta分析
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【摘要】目的综合评价CYP1A1基因多态性与女性子宫内膜癌遗传易感性的关联度。方法 KI、维普和PUBMED数据库,获取CYP1A1基因多态性与女性子宫内膜癌易感性关系的病例对照研究。以子宫内膜癌组与对照组人群基因型分布的OR值为效应指标,采用REVMAN 软件进行Meta分析,并根据一致性检验的结果选用合适的模型进行数据的合并。结果入选文献共4篇,其中英文文献1篇,中文文献3篇,累计病例数和对照数分别为908和1 585例。(纯合子模型)(95 %CI:~)。CYP1A1 CT(杂合子模型)(95 %CI:~),(95 %CI:~)。结论 CPY1A1的基因多态性与子宫内膜癌的易感性有关。
【关键词】 CYP1A1; 基因多态性; 子宫内膜癌; Meta分析
【Abstract】 Objective To evaluate the relationship between CYP1A1 gene polymorphism and the risk of endometrial cancer among females. Methods A Metaanalysis was performed using published reports with a casecontrol design. Results Four casecontrol studies consisting of 908 endometrial cancer cases and 1 585 controls were included. Pooled odds ratio (OR) of and CYP1A1 CT puted with CYP1A1 TT as the reference group. Women carrying genotype had an OR of (95 %CI:), and women carrying a CT genotype had an OR of (95 %CI: 0 with the TT genotype. The pooled OR of allele C vs T was (95 %CI:). Conclusion CYP1A1 gene polymorphism is associated with the susceptibility of endometrial cancer.
【Key words】 CYP1A1; Polymorphism; Endometrial cancer; Metaanalysis
子宫内膜癌是妇科最常见的恶性肿瘤之一,中国是子宫内膜癌低发国家,但近年来患病率呈升高趋势[1]。其发病原因目前尚无定论。流行病学人群研究认为,其发生与长期激素刺激及体质因素如高血压、糖尿病、肥胖等有关。