文档介绍：HER2在膀胱尿路上皮癌中的表达及意义
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【摘要】目的检测 HER2在膀胱尿路上皮细胞癌、癌旁黏膜、正常膀胱黏膜组织中的表达,探讨HER2表达与膀胱尿路上皮细胞癌临床特征、病理分级、临床分期间的关系,评价它是否可以作为判断膀胱尿路上皮细胞癌生物学行为的指标。方法收集临床病理资料完整的膀胱尿路上皮癌及相应癌旁组织各50例,正常膀胱组织20例,应用免疫组化法(SP法)检测HER2蛋白的表达。结果 HER2蛋白在膀胱尿路上皮细胞癌组织中的表达高于癌旁黏膜和正常膀胱黏膜中的表达,差异有统计学意义();HER2蛋白的表达和病理分级、肿瘤大小有相关性,差异有统计学意义()。结论 HER2蛋白表达和肿瘤的病理分级、肿瘤大小等有相关性,表明HER2蛋白过表达可能与膀胱癌的发生和发展密切相关。
【关键词】膀胱尿路上皮细胞癌;HER2基因;相关性
【Abstract】 Objective To study the expression of HER2 in uroepithelium cell carcinoma of bladder,mucosa in the paracarcinoma and normal mucous of urinary bladder,and to explore its correlation with clinic factors,grade and stage of the bladder carcinoma and evaluate whether HER2 can serve as marker to decide the biological behavior of bladder 50 specimens of uroepithelium cell carcinoma of bladder,50 specimens mucosa in the paracarcinoma and 20 cases normal mucous of urinary bladder were protein expression of HER2 was detected by immunohistochemical staining SP The expression of HER2 protein in uroepithelium cell carcinoma of bladder tissues was significant higher than that in paracarcinoma mucosa and normal mucous of urinary bladder (). The expression of HER2 protein in uroepithelium cell carcinoma of bladder tissues had dependablity correlation with the grade and size of the tumors ().Conclusion The expression of HER2 protein in uroepithelium cell carcinoma of bladder tissues had significant correlation with the gr
ade and size of the tumors. It illustrates that the over expression of HER2 protein maybe had highly correlation with the oncogenesis and development of bladder cancer.
【Key words】 uroepithelium cell carcinoma of bladder;HER2 gene;dependablity
膀胱尿路上皮细胞癌(uroepithelium cell carcinoma of bladder,UCCB)是我国泌尿系统最常见的恶性肿瘤,年发病率约为6/10万。该肿瘤的特点为:易复发,难以早期诊断和估计预后[1~2]。寻找有价值的用于癌的早期诊断和判断预后的肿瘤标志物成为当前人们研究的热点之一。HER2基因(亦作c
erB2或Her2/neu)是人表皮生长因子受体(Human Epidermal Growth Factor receptor,HE