文档介绍：Survivin、Bcl2在I期NSCLC中的表达及其临床意义
(作者:___________单位: ___________邮编: ___________)
【摘要】目的手术后I期非小细胞肺癌的预后情况与众多因素有关,凋亡相关基因在肿瘤的发生发展过程中发挥重要的作用。本研究通过检测凋亡相关基因Survivin及Bcl2在I期非小细胞肺癌中的表达情况,探讨其在I期非小细胞肺癌的临床意义和预后价值。方法利用免疫组化学技术检测85例I期非小细胞肺癌(NSCLC)及20例肺良性肺组织中Survivin和Bcl2的表达,统计分析这两者在I期非小细胞肺癌的作用。结果 85例I期非小细胞肺癌组织中Survivin和Bcl% (55/85) %(45/85)与正常肺组织中的表达差异显著();多因素分析显示 PTNM分期与Survivin蛋白的阳性表达是I期非小细胞肺癌患者独立预后因素(),Survivin、Bcl2蛋白的表达与临床、病理各因数无相关。结论在I期非小细胞肺癌中,凋亡相关基因Survivin及Bcl2可能对肿瘤的发展与预后产生一定的作用与影响;PTNM分期与Survivin蛋白的阳性表达是此Ⅰ期非小细胞肺癌术后患者的独立预后因素。
【关键词】肺肿瘤;癌;非小细胞性;Survivin;Bcl
2
ABSTRACT:Objective To investigate the expression of the representative apoptosisrelated oncogene survivin and Bcl2 in stage I nonsmall cell lung cancer and its clinical The expression of survivin and Bcl2 was detected by using Labelled Streptavidin Biotin immunohistochemistry assay in 85 NSCLC stage I surgical specimens and 20 benign disease specimens. Results The positive rates of survivin and Bcl2 were % (55/85) and %(45/85), respectively, there was significant difference between tumour and nontumour (P ). PTNM stage and positive expression of survivin were independent prognostic factors of stage I NSCLC . Conclusion In stage I NSCLC, apoptosisrelated oncogene may be important to the occurrence and development of lung cancer; PTNM stage and positive expression