文档介绍：奥曲肽联合腹腔化疗治疗晚期胃癌疗效观察
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作者:江兴松,张南征,朱云,杜文琪,马文青,封安强
【摘要】目的评估奥曲肽(octreotide,OCT)联合腹腔化疗治疗晚期胃癌的临床疗效。方法对52例晚期胃癌患者应用奥曲肽联合5-氟脲嘧啶(5-Fu)腹腔化疗(治疗组),并与同期49例采用单纯5-Fu腹腔化疗的晚期胃癌患者(对照组)比较。结果治疗组的腹水治疗有效率、、1年及2年生存率显著优于对照组。结论奥曲肽联合腹腔化疗可提高晚期胃癌的临床疗效,是行之有效的综合治疗方法。
【关键词】晚期胃癌;奥曲肽;5-氟脲嘧啶;腹腔化疗
Abstract: Objective To evaluate the clinical curative effects on bined with intra-abdominal chemotherapy in advanced gastric cancer. Methods 52 patients with advanced gastric cancer were treated with octreotide plus intra-abdominal chemotherapy with 5-fluorouracil (5-Fu), and were designated as study group. Meanwhile, another 49 patients undergoing intra-abdominal chemotherapy with 5-Fu alone served as the control group. Results The efficacy of treatment for ascites, Karnofsky scores, survival rate of yr, 1 yr and 2 yr in the study group were significantly higher than those in the control group. Conclusion bined with intra-abdominal
chemotherapy is able to improve the clinical curative effects on advanced gastric cancer and is a preferable method prehensive treatment.
Key words: advanced gastric cancer; octreotide; 5-fluorouracil; intra-abdominal chemotherapy
胃癌是我国常见的恶性肿瘤之一,多数患者确诊时已属晚期,从而失去了手术根治的机会。有实验表明,生长抑素类似物(somatostatin analog,SSA)对胃癌细胞株生长有较强的抑制作用。我院自2004年1月—2008年12月首先应用奥曲肽联合5-氟脲嘧啶(5-Fu)腹腔化疗治疗晚期胃癌52例,与单纯腹腔化疗者49例比较疗效,报告如下。
1 资料和方法
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