文档介绍：白介素-6对冠心病患者高敏C反应蛋白水平影响及意义
(作者:___________单位: ___________邮编: ___________)
作者:王守力,韩雅玲,刘丽军,阎承惠,康健
【摘要】目的: 探讨白细胞介素6(IL-6)及高敏C反应蛋白(hs-CRP)在冠心病心绞痛发病机制中的作用. 方法: 选择住院的心绞痛患者170例,分为不稳定型心绞痛组86例,稳定型心绞痛组84例,另40健康人作为对照组. 采用酶联免疫吸附(ELISA)法测定血浆IL-6水平,免疫浊度法(奥林巴斯全自动生化仪)测定hs-CRP. 结果: 不稳定型心绞痛组血浆IL-6,hs-CRP水平分别为(±)pg/L,(±)μg/L高于稳定型心绞痛组的(±)pg/L,(±)μg/L(P<),两组与正常对照组的(±)pg/L,(±)μg/L相比,差异有统计学意义(P<). 相关分析表明IL-6与hs-CRP正相关(rs=,P<). 结论: IL-6可能通过激发炎症反应,导致hs-CRP水平增高,在冠心病的发生、发展及演变过程中起重要作用.
【关键词】冠状动脉疾病冠状血管造影术 C反应蛋白质白细胞介素-6
【Abstract】AIM: To vestigate the roles of IL-6 and hs-CRP in development of coronary heart disease(CHD). METHODS: 170 cases of angina pectoris were enrolled in the study,including 86 patients with unstable angina pectoris(UAP group) and 84 patients with stable angina pectoris(SAP group). Forty healthy subjects were taken as controls(Control group). The level of IL-6 was measured with level of hs-CRP was measured with ratenephelometry. RESULTS: The level of IL-6 and hs-CRP were singnificantly higher in UAP group than in SAP group,[(±) vs (±)pg/L,P<,(±) vs (±)μg/L,P<]. They were singnificantly higher than those in control group[(±)pg/L,P<,(±)μg/L,P<]. Multiple Logistic regression analysis indicated that IL-6 was an independent risk for the stability of