文档介绍：A在前列腺癌中表达的意义及相关性分析
作者:汤群辉杨力军王禾陈宝琦王鹏飞武国军
【关键词】前列腺肿瘤
关键词: 前列腺肿瘤;增殖细胞核抗原;视网膜母细胞瘤基因;免疫组织化学
摘要:目的探讨视网膜母细胞瘤易感基因(Rb)和增殖细胞核抗原(PCNA)在前列腺癌中表达的意义及其相互关系. 方法 A进行检测,并应用图像分析仪及统计学方法对两者在不同病理分级及临床分期中的表达进行对比及相关分析. 结果 36例前列腺癌标本中Rb表达阳性17例,%,其表达在前列腺癌的不同病理分级及临床分期之间有显著差异(P<);PCNA在标本中的表达强度在不同病理分级及临床分期之间有显著差异(P<);A表达存在负相关,即Rb阳性标本中PC-A表达强,两者比较有显著性差异(P<). 结论 Rb基因参与了前列腺癌的发生、发展过程,A调节通路的异常,A有助于前列腺癌恶性程度的判定及预后.
Keywords:prostatic neoplasms;proliferating cell nuclear antigen;retinoblastoma genes;immunohis-tochemistry
Abstract:AIM To discuss the expression and correlation of retinoblastoma susceptibility gene and proliferating cell nu-clear antigen in the prostatic SABC immunohistochemistry was used to determinate Rb gene and PCNA in36samples of the prostatic image pat-tern analyzer and the statistics methods were used to do parative analysis of Rb gene and PCNA in the different pathological grading and clinical phases of the prostatic can┐ immunohistochemistry staining was Rb pos-itive in17of36samples,%.The expression of Rb had significant differences in different pathological grading and clinical phases(P<).The expression of PCNA also had significant differences in different pathological grading and clinical phases(P<).The expression of PCNA was weak in the Rb positive expression samples and was strong in the Rb negative expression was a significant difference between Rb and PCNA expression(P<).CONCLUSION Rb is involved in the occurrence and devel-opment of the prostatic for pathological mecha-nism,it is related to the abnormality of Rb and PCNA regu-lating determination of Rb and PCNA can be an in-dex for estimating the level of malignant and progression of the prostatic cancer.
0 引言
前列腺癌是威胁人类生命的恶性肿瘤之一,自20世纪70年代以来我国前列腺癌的发病率明显升高,对前列腺癌的诊治已日益受到重视[1] .A在细胞周期及DNA复制的过程中起着重要的作用,A进行检测,对两者在不同病理分级及临床分期中的表达进行了对比及相关分析.
1 材料和方法
材料收集1982/19