文档介绍：不同方法应用胞二磷胆碱治疗中、重度新生儿缺氧缺血性脑病76例疗效观察
【摘要】目的研究不同方法应用胞二磷胆碱治疗中、重度新生儿缺氧缺血性脑病(HIE)的疗效及对预后的影响,为临床治疗提供参考依据。方法将76例中、重度HIE患儿随机分为对照组和治疗组,两组均在原有支持疗法和对症处理的基础上,加用胞二磷胆碱治疗HIE,对照组应用胞二磷胆碱的方法是01~0125g/次,加入5%~10%葡萄糖注射液20 ml中qd drip,10天为1个疗程,间隔10~20天,用下一个疗程,共3个疗程。而治疗组应用胞二磷胆碱的方法也是01~0125g/次,加入5%~10%葡萄糖注射液20 ml中qd drip,10天为一个疗程,但不同的是连续应用3个疗程,中间不用间隔时间。最后对两组临床疗效及预后比较。结果两组呼吸改善时间、惊厥消失时间差异无显著性,无统计学意义,但症状、体征全部消失时间及后遗症发生率,治疗组明显低于对照组,具有统计学意义(P<005)。结论胞二磷胆碱连续应用3个疗程,中间不用间隔时间的方法治疗中、重度HIE有助于改善患儿预后,降低后遗症发生率。
【关键词】胞二磷胆碱;缺血缺氧性脑病;新生儿;疗效
[Abstract] Objective To observe the curative effect and prognosis of HIE with different methods of cytidine diphosphate choline,provide a reference basis for clinical treatment. Methods 76 cases moderate and severe HIE childr
en were randomly divided into treatment group and control group and two groups were in the original support therapy and symptomatic treatment,on the basis of bined with cytidine diphosphate choline,control group with cytidine diphosphate choline was 01~0125g times,add 5%~10% glucose 20 ml qd ivgtt,10 days for a period of treatment,the interval was 10~20 treatment group with cytidine diphosphate choline was ~0125g times,add 5%~10% glucose 20 ml qd ivgtt,10 days were for a period of treatment,but the difference was continuous application without treatment two groups of clinical curative effect and prognosis pared. Results