文档介绍：乙型肝炎病毒宫内感染的机制
作者:闫永平徐德忠王福生门可刘志华

【关键词】肝炎病毒
关键词: 肝炎病毒,乙型;妊娠并发症;病例对照研究;免疫组织化学;原位杂交

摘要:目的探索乙型肝炎病毒(HBV)宫内传播的机制和时间. 方法孕妇和新生儿血清HBsAg和HBV ,HBxAg,HBcAg和HBV DNA检测采用ABC免疫组化染色和原位杂交. 结果母亲外周血HBV高浓度(≥&#12539;L-1 )、先兆早产和胎盘绒毛毛细血管内皮细胞HBV感染导致宫内感染发生的危险性比值比(OR),、,从母面蜕膜细胞至胎儿面绒毛毛细血管内皮细胞HBV感染率呈逐渐下降趋势, DNA和抗原. 结论胎儿宫内感染的发生可经2条途径,,但主要时期是在孕晚期.

Keywords:hepatitis B virus;plications;case-control studies;immunohistochemistry;in situ hybridization

Abstract:AIM To explore the mechanism and timing of hepatitis B virus(HBV)intrauterine Serologic HBV infection markers of pregnant women and newborns were detected by ELISA and ,HBx-Ag,HBcAg and HBV DNA in placentas and fetal abortion liver tissue were determined by ABC immunohistochemical staining and in situ Intrauterine infection ORs of high concentration(≥&#12539;L-1 )of HBV in maternal peripheral blood,threaten premature labour and placental villous capillary endothelial cell(VCEC)infec-tion ,, infection extent in placenta became gradually serious with the continu-ing of pregnant placental infection gradually near to fetal side from maternal side,the OR of intrauterine infection had