文档介绍：冠心病患者血压晨峰水平与冠脉病变程度关系的临床研究
作者:范泉梁卓燕陶小红邱欣良
【摘要】目的探讨血压晨峰(MBPS)水平与冠状动脉病变严重程度的关系及意义。方法收集93例拟行选择性冠状动脉造影(CAG)患者,分为正常对照组24例、单纯冠心病组22例、冠心病合并高血压组47例。所有患者入院后测量血压晨峰,根据住院期间CAG结果,分别采用冠脉病变支数和冠脉狭窄程度积分统计冠脉狭窄程度,作为冠脉病变程度的指标。结果冠心病合并高血压组的血压晨峰水平及冠脉狭窄程度均较单纯冠心病组明显升高(P<);单纯冠心病组冠脉狭窄程度明显高于正常对照组(P<);冠心病合并高血压组中MBPS<25 mmHg亚组与MBPS≥25 mmHg亚组间血压水平无统计学差异,血压晨峰水平、冠脉狭窄程度方面有统计学差异(P<)。相关分析显示,血压晨峰水平与冠脉病变程度呈正相关,在剔除了其他常见影响因素后这种相关性仍然存在。结论 MBPS水平与冠脉病变程度呈正相关。MBPS水平升高是冠心病的独立危险因素。
【关键词】冠心病高血压血压晨峰冠脉狭窄程度
Abstract: Objective To explore the relationship between the level of morning blood pressure surge (MBPS) and the extent of coronary lesions in coronary heart disease (CHD). Methods 93 patients undergoing selective coro
nary angiography (CAG) were divided into: contrast group (n=24), simple CHD group (n=22), CHD panied with essential hypertension (EH) group (n=47). The levels of MBPS of all the patients were measured. All the patients also had coronary angiography and the degree of coronary artery disease was denoted with the coronary number of stenosis and the score of coronary lesion. Results The levels of MBPS and the degree of coronary artery stenosis in CHD panied with EH group were significantly higher than those of simple CHD group (P<). The degree of coronary artery stenosis of simple CHD were significantly higher than those of control group (P<); The levels of MBPS and th