文档介绍：R5、
【关键词】慢性乙型肝炎;,辅助T细胞亚群
摘要:目的研究辅助性T细胞亚群(Th)在慢性乙型肝炎(CHB)发病机制中的作用,寻找治疗CHB的新方法。方法用流式细胞仪对20例正常人(NC组)及20例CHB患者外周血单核细胞(PBMC)经植物血凝素(PHA)培养前后的Th1、Th2水平进行了检测,Th1、R5、。结果培养前,Th1在NC组与CHB组无明显差别(P>),CHB组Th2明显高于NC组,同时CHB组及NC组Th1均明显高于Th2(P<);培养后,NC组的Th1较培养前明显减少(P<),而NC组的Th2、CHB组的Th1及Th2较培养前均明显增加(P<),而以CHB组的Th2增加更明显;培养后,CHB组Th1、Th2均高于NC组(P<),而CHB组及NC组的Th1与Th2之间则无明显差别(P>);培养前CHB组明显低于NC组(P<),而培养后CHB组高于NC组(P<),(P<)。结论 CHB患者体内Th细胞亚群的应答模式与正常人群存在一定的差异;Th1向Th2细胞的漂移与乙型肝炎的慢性化及反复肝损伤有一定的关系。
关键词:慢性乙型肝炎;辅助T细胞亚群
Abstract:Objective To investigate the roles of T helper(Th)cell subtypes in the pathogenesis of chronic hepatitis B(CHB)to help find new therapies for The expression levels of R5(Th1)and (Th2)of PMBC were assayed by flow cytometry in20CHB patients and20normal controls(NC)before and after PHA
the specific cell surface markers for Th1and Before cultivation,there was no discrepancy in Th1between NC and CHB(P>);Th2was higher in CHB than in NC;and Th1was higher than Th2in both CHB and NC(P<).After cultivation,Th1was decreased,but Th2was increased in NC;while Th1and Th2were both increased greatly in CHB,especially Th2(P<).Th1and Th2in CHB were both higher than those in was no discrepancy