文档介绍：过敏性紫癜病儿血清P选择素的表达及其意义
【摘要】目的探讨血清P选择素与儿童过敏性紫癜(HSP)及紫癜性肾炎(HSPN)的相关性。方法采用ABCELISA法检测56例HSP病儿急性期和恢复期血清P选择素表达水平,35例健康儿童作为正常对照组。以尿常规检查结果将HSP病儿分为HSPN组(24例)和非紫癜性肾炎(nHSPN)组(32例),比较不同组及不同病期血清P选择素表达水平差异。结果急性期nHSPN、HSPN组病儿可溶性P选择素表达水平均明显高于正常对照组(F=,q=、,P&lt;);HSPN组较nHSPN组P选择素表达水平明显增高(q=,P&lt;)。nHSPN、HSPN组病儿恢复期P选择素表达水平较急性期明显降低(t=、,P&lt;),但较正常对照均仍明显增高(F=,q=、,P&lt;)。结论血清P选择素异常表达与HSP发病发展有关,其对HSP病情变化监测具有一定的参考价值。
【关键词】紫癜,过敏性;肾炎;P选择素
[ABSTRACT] Objective To investigate the relationship between Pselectin and HenochSchonlein purpura(HSP) and purpuric nephritis (PN) in children. Methods By using ABCELISA, the serum Pselectin was detected in 56 HSP children at acute stage and recovery phase. The children were divided into two groups, PN group and NonPN group, based on routine urinalysis. The levels of serum Pselectin of different groups and different phases pared. The control group consisted of 35 healthy children. Results In acute s
tage, the levels of Pselectin in PN and NonPN groups were significantly higher than those in normal controls (F=;q=,;P&lt;), and much lower at convalescence (t=,;P&lt;), but still higher than that of the normal children (F=;q=,;P&lt;). Conclusion The abnormal expression of serum Pselectin is associated with the pathogenesis and progression of HSP, a