文档介绍：万方数据万方数据上海交通大学硕士学位论文I 阿尔茨海默症医学影像数据管理与分析摘要近年来,随着医学影像技术的迅速发展,并开始广泛应用于临床和医学基础研究,产生了大量的医学影像数据信息。这些数据信息不仅是临床诊断的重要依据,同时还是疾病相关研究的宝贵资源。与此同时,通过影像学的角度发现疾病的病变规律或者特点,实现临床的辅助诊断,也逐渐成为疾病研究的热点。医学影像数据的管理以及相关的影像数据分析便在这个趋势下逐渐发展起来了。目前,在阿尔茨海默症数据管理方面,国内尚无一个健全的能够为临床和科研提供一个资源共享的平台系统。针对这种需求,并根据医学影像的数据特点,以及临床和科研的需要,标准,结合临床上一些评定量表的信息,设计了一个医学影像数据库,实现影像相关数据的存储与查询。除了影像数据的管理功能,我们也尝试为开发的系统提供分析工具并利用其分析我们所收集的影像数据。例如,在阿尔茨海默症影像数据分析方面,PET数据由于其能够在早期反应功能代谢信息的独特优势,成为临床和科研分析的热点。为了能够实现阿尔茨海默症的分类诊断,我们对FDG PET数据进行特征提取,然后使用支持向量机的方法进行分析。最后,通过对几种特征提取方法的结果比较分析,评估其临床可用性。结果表明,通过我们的数据管理系统,可以方便地获取相应的数据信息,实现了数据资源的共享。同时,FDG PET数据的分类结果也能够为临床提供一个较高的分类精度,具有一定的临床诊断意义。万方数据上海交通大学硕士学位论文II 关键词:阿尔茨海默症,医学影像数据管理,特征提取,分类万方数据上海交通大学硕士学位论文III The Management and Analysis of Medical Image Data for Alzheimer’s DiseaseABSTRACT With the rapid development of medical imaging technologies, and their wide applications in clinical diagnosis, basic medical research and clinical trials, there existed huge amount of medical image data. The information contained in them is extremely rich and forms the basic resource for clinical diagnosis, and for disease related study. One important use of the medical imaging data is in the area of puter-aided diagnosis which es more widely accepted. Alzheimer’s disease (AD) databases have been long developed and well maintained in developed countries. However in China, no widely accepted database system is accessible to AD researchers and clinicians. In order to share resources and help accelerate new research on AD, we built an integrated database that systematically stores, organizes, and manages raw and processed AD related data previously and newly collected at multiple centers. This database not only contains integrated imaging, demographic, genomic, cognitive test, clinical and various other biomarker data types for easy access and analysis but also includes analytic tools as a part of the system. Here,as a validation of the tools we implemented and in order to realize the classification of Alzheimer's di