DCC基因多态性与大肠癌遗传易感性的相关研究.doc

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DCC 基因多态性与大肠癌遗传易感性的相
关研究#
刘晓明,孙明军**
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(中国医科大学附属第一医院内镜中心,沈阳 110001)
摘要:目的:探讨 DCC 基因 rs7504990 位点 SNP 与中国大肠癌遗传易感性。方法:本研究
搜集中国人大肠癌患者 475 例,健康体检者 193 例,提取其外周静脉血中 DNA,采用 Taq man
探针法检测其 rs7504990 位点 SNP。结果:rs7504990 位点其中 TC、TT 及 TC+TT 基因型在
病例组与对照组的比较中均呈现显著统计学差异, 基因型和 TC 基因型
在癌症家族史的比较中存在明显统计学差异。结论:DCC 基因 rs7504990 位点 SNP 可显著
增加中国人大肠癌发病风险,其中大肠癌高发人群中无癌症家族史者,更具重要意义。
关键词:消化内科;大肠癌;DCC 基因;单核苷酸多态性;Taq man 探针
中图分类号:R
DCC gene polymorphism and ic susceptibility to
colorectal cancer related research
LIU Xiaoming, SUN Mingjun
(Department of gastrointestinal endoscopy, the first hospital of China Medical
University,Shenyang 110001)
Abstract: Objective: to study the DCC gene SNP rs7504990 locus and ic susceptibility to
colorectal cancer in China. Methods: in this study to collect the Chinese 475 cases of colorectal
cancer patients, 193 controls of healthy check-up, extract the DNA in the peripheral venous blood,
using Taq man
Their site SNP rs7504990 probe method. Results: rs7504990 loci of TC, TT and TC + TT
genotype in the case group and control group were statistically significant differences between, in
parison of the cases of group, genotype and TC genotype were significant
differences in parison of family history of cancer. Conclusion: DCC gene SNP rs7504990
locus can significantly increase the risk of the colorectal cancer, includin