miRNAs与头颈部肿瘤的研究进展.doc

文档介绍：
miRNAs 与头颈部肿瘤的研究进展#
赵娟霞1,2,石必枝1,潘晓蓉1**
(1. 上海交通大学医学院附属仁济医院上海市肿瘤研究所,上海 200032;
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2. 南华大学附属南华医院病理科,衡阳 421002)
摘要:miRNAs 参与了细胞的多种生命活动。深入研究不同种类的头颈部肿瘤中特定 miRNAs
的表达以及对相关基因的调控,可以更好地阐明头颈部肿瘤的发病机制,为分子靶向治疗提
供新的靶标。本文主要研讨 miRNAs 与头颈部肿瘤相关基因表达调控的研究进展。
关键词:头颈部肿瘤;miRNAs;基因表达调控
中图分类号:
Progress of Research on miRNAs and Head and Neck
Cancer
ZHAO Juanxia1,2, SHI Bizhi1, PAN Xiaorong1
(1. Shanghai Cancer Institute, Renji Hospital, Shanghai Jiao Tong University School of Medicine,
Shanghai 200032;
2. Department of Pathology, Nanhua Hospital, University of South China, Hengyang 421002)
Abstract: miRNAs has been involved in the modulation of several biological activities of cells.
The expression of miRNAs and the regulation of related genes were deeply investigated in various
head and neck cancer, which contributed to reveal pathogenesy of head and neck cancer and find
some specific markers of molecular targeted therapy. In this review, we described the progress of
research on miRNAs and head and neck cancer.
Key words: head and neck cancers; miRNAs; the regulation of gene expression
0 引言
头颈部肿瘤构成世界上六大常见恶性肿瘤之一,包括喉癌、口腔癌、舌癌、甲状腺癌和
鼻咽癌等[1]。引起这类疾病的主要危险因素有吸烟、酗酒和人乳头状病毒感染[2-4]。尽管在
过去 10 年里诊断方法,外科和放疗治疗手段都有了很大的改进,但是,其 5 年的生存率仍
然在 50%左右,是死亡率高的几个主要恶性肿瘤之一。头颈部肿瘤由于诊断的时候常常已
是晚期,局部和远处的转移往往导致其较低的生存率。目前对头颈部肿瘤的发生发展机制不
是很清楚。近年来,越来越多的证据证明,miRNAs 在头颈部肿瘤的发生发展中起着重