文档介绍：中药黄芩抗缺氧作用研究高卫,蒋秀芳,范春梅,郑菊花,王丹(大连大学医学院,辽宁大连116622)*摘要:目的:为探讨黄芩水提物的抗缺氧作用,:采用小鼠常压缺氧模型、对抗异丙肾上腺素模型、对抗亚硝酸钠动物模型,腹腔注射黄芩水提物,:黄芩水提物能显著延长常压缺氧条件下小鼠的存活时间(P<0?01);能显著延长腹腔注射异丙肾上腺素小鼠在常压缺氧条件下的存活时间(P<0?01);对小鼠亚硝酸钠中毒无明显的缓解作用(P>0?05).结论::黄芩;缺氧;存活时间中图分类号:R282文献标识码:A文章编号:1008-2395(2006)02-0094-03Studyoneffectsofanti-anoxiaofbaikalskullcaprootGAOWe,iJIANGXiu-Fang,FANChun-me,iZHENGJu-hua,WANGDan(MedicalCollege,DalianUniversity,Dalian116622,China)Abstract:[Objecive]Forstudyontheanti-anoxiaeffectsofthehydro-extractsofBaikalSkullcapRoot,[Methods]Toinjectthehydro-extractsfromBaikalSkullcapRootintoabdominalcavityofmicemodelswhichwerepreparedasthenormalpressureanoxiaanimalmodels,anti-Isoproterenol(IP)animalmodelsandanti-erinitritanimalmodels,andmeasuretheirsurvivaltime.[Results]Thehydro-extractsfromBaikalSkullcapRootcansignificantlyprolongthesurvivaltimeofthenormalpressureanoxiamicemodelandthenormalpressureanoxiamicemodelwhichhavebeeninjectedtheIPintotheirabdominalcavity(P<0?01),butithasnotanytransparentremissioneffectsonthemicewhichhavebeenpoisonedbyerinitrit(P>0?05).[Conclusion]Thehydro-extractsofBaikalSkullcapRootcanreinforcetheabilityofanti-:BaikalSkullcapRoot;anoxia;survivaltime中药黄芩为唇形科植物黄芩(i)的根,味苦性寒,具有清热燥湿、泻火解毒、止血安胎的功效,是我国传统常用中药[1].近年来对黄芩的药理作用研究表明,黄芩具有抑菌、利尿、抗炎、抗变态反应、解痉及降压作用[2].