文档介绍：
参芪复方对 GK 大鼠肾脏 PPARγmRNA 的
影响#
郭保根1,孙凤平2,殷丽平1,谢春光1**
5
10
(1. 成都中医药大学临床医学院,成都 610075;
2. 厦门市第一医院,福建厦门 361003)
摘要:目的:观察参芪复方对 GK 大鼠肾脏过氧化物酶体增殖物激活受体γmRNA(PPAR
γmRNA)表达的影响及其可能的作用机制。方法:将随机血糖≥ 的 GK 大鼠
40 只随机分为雷米普利组、参芪复方高剂量组、参芪复方低剂量组、模型组四组,正常 SD
大鼠 10 只作为空白组。8 周后以 RT-PCR 法测定大鼠肾 PPARγmRNA 的表达。结果:参
芪复方高剂量组 GK 大鼠肾 PPARγmRNA 表达增强,和模型组比较有统计学意义(P<)。
结论:参芪复方高剂量能够增强 PPARγ活性,可能是其降低血糖,抑制 DN 发生、发展的
作用机制之一。
关键词:参芪复方;GK 大鼠;NF-ΚBmRNA;PPARγmRNA
15
Effects Of pound Recipe On Nuclear Factor
ΚBmRNA And PPARγmRNA In Kidney Of GK Rats
GUO Baogen1, SUN Fengping2, YIN Liping1, XIE Chunguang1
(1. College of Clinical Medicine,Chengdu University of TCM, ChengDu 610075;
20
25
30
35
2. The first hospital of Xiamen City, FuJian XiaMen 361003)
Abstract: Objective:To observe the effects of pound Recipe on the express of
PPARγmRNA in Kidney of GK Rats and its possible mechanisms. Methods:The 40 GK rats,
RBG≧, were randomly divided into Ramipril group, the pound Recipe
high dose group, the pound Recipe low dose group, and model group. 10 normal SD
rats were set as the control group. After administered for 8 weeks, the expression of PPARγmRNA
were determined from right kidney by RT-PCR way. Results:The expression of the PPARγmRNA
increased,having statistically pared with the model group(P<). Conclusions:
The pound Recipe high dose group can lower the gluc