文档介绍：HPLC法测定咳速停胶囊中盐酸麻黄碱含量方法改进【摘要】目的:对咳速停胶囊中盐酸麻黄碱含量测定方法进行改进。方法:采用高效液相色谱法,选用UItimateAQ-C18色谱柱(×250mm,5μm);流动相:甲醇-乙腈--1磷酸二氢钾溶液()(5:1:94);流速:?min-1;紫外检测波长:210nm。结果:,(r=),%(n=6),RSD,%。结论:本方法准确、可靠,可作为咳速停胶囊质量控制的方法。【关键词】咳速停胶囊;盐酸麻黄碱;含量测定;方法改进ToimprovetheContentDeterminationMothedofEphedrineHydrochlorideinKesutingCapsulebyHPLCHELi1,TANGXiao-bo2,wangJiaping3;ChaiJun3(1ConstructionHospital,pany,HunanProvince,Changsha410007;2ZhejiangBetterPharmaceuticalsCo.,Ltd.,Shaoxing312071;3ShaoxingInstituteforFoodandDrugControl,ZhejaingShaoxing312071)【Abstract】Objective::TheUItimateAQ-C18(×250mm,5μm),acetonitrile,-1potassiumdihydrogenphosphate()(5:1:94),?min-1,:,(r=),%%(n=6).Conclusion:urateandreliable,couldbeusedinthequalitycontrolofephedrinehydrochlorideinKesutingCapsule.【Keywords】HPLC;XiaoKeGranule;Ephedrinehydrochloride;Contentdetermination咳速停胶囊是由吉祥草、黄精、白尾参、桔梗、虎耳草、批把叶、麻黄、桑白皮和罂粟壳九味中药组成的复方制剂,具有补气养阴,润肺止咳,益胃生津等功效。用于感冒及慢性支气管炎引起的咳嗽,咽干,咯痰,气喘。该药现行标准对盐酸麻黄碱进行含量测定,重现性差,提取所用的溶剂毒性大,且原标准色谱条件下出峰时间较长。